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Secondary myelodysplastic syndromes following peripheral blood stem cell transplantation: morphological, cytogenetic and clonality evaluation and the limitation of FAB criteria

Bone Marrow Transplantation volume 26, pages 241–242 (2000)Cite this article

We read with interest the article of Amigo et al1 dealing with the diagnosis of secondary myelodysplastic syndrome (MDS) following autologous transplantation. The authors believe that the application of FAB criteria for diagnosis of MDS after autologous transplant is questionable since the concomitant presence of cytopenia and myelodysplasia was observed in 25% of patients at 12 months and they could therefore, diagnose MDS according to FAB classification. On the basis of our experience we can confirm these statements.

Since 1996 we studied 52 patients (21 F; 31 M) submitted to peripheral blood selected (CD34+) (16 patients) or unselected autologous stem cell transplantation (36 patients). Reasons for transplantation were non-Hodgkin's lymphoma (26 patients), Hodgkin's lymphoma (13 patients) and multiple myeloma (13 patients). The purpose of the study was to detect MDS/sAML after transplantation and any morphological dysplasia, cytogenetic or clonality alterations.23 All patients entering the study had had at least 12 months follow-up and had to be in continuous complete remission after PBPCT without receiving any chemoradiotherapy or biological response modifier.

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References

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  1. Department of Hematology, Istituto di Semeiotica Medica, Universita’ Cattolica Sacro Cuore, Policlinico A Gemelli, Largo A Gemelli, 8, Roma, 00168, Italia

    L Laurenti, G d'Onofrio, S Sica, P Chiusolo, G Zini, N Piccirillo, M Zolliino, M Garzia, F Sora & G Leone

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  1. L Laurenti
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  2. G d'Onofrio
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  3. S Sica
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  4. P Chiusolo
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  7. M Zolliino
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  10. G Leone
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Laurenti, L., d'Onofrio, G., Sica, S. et al. Secondary myelodysplastic syndromes following peripheral blood stem cell transplantation: morphological, cytogenetic and clonality evaluation and the limitation of FAB criteria. Bone Marrow Transplant 26, 241–242 (2000). https://doi.org/10.1038/sj.bmt.1702502

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