Abstract
Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects. Bone Marrow Transplantation (2000) 26, 347–350.
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References
deVries CR, Freiha FS . Hemorrhagic cystitis: a review J Urol 1990 143: 1–9
Echavarria MS, Ray SC, Ambinder R et al. PCR detection of adenovirus in a bone marrow transplant recipient: hemorrhagic cystitis as a presenting manifestation of disseminated disease J Clin Microbiol 1999 37: 686–689
Arthur RR, Shah KV, Baust SJ et al. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants New Engl J Med 1986 315: 230–234
Kawakami M, Ueda S, Maeda T et al. Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation Bone Marrow Transplant 1997 20: 485–490
Laszlo D, Bosi A, Guidi S et al. Prostaglandin E2 bladder instillation for the treatment of hemorrhagic cystitis after allogeneic bone marrow transplantation Haematologica 1995 80: 421–425
Andrei G, Snoeck R, Vandeputte M et al. Activities of various compounds against murine and primate polyomaviruses Antimicrob Agents Chemother 1997 41: 587–593
Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 1998 91: 756–763
Miller J, Burfield GD, Moretti KL . Oral conjugated estrogen therapy for treatment of hemorrhagic cystitis J Urol 1994 151: 1348–1350
Biel SS, Gelderblom HR . Electron microscopy of viruses. In: Cann AJ (ed) Cell Culture – A Practical Approach Oxford University Press: Oxford 1999 pp111–147
Biel SS, Nitsche A, Bae HG et al. Quantification of polyomavirus in urine of bone marrow transplant recipients Acta Microbiol Immunol Hung 1999 46: 375–376
Nevo S, Swan V, Enger C et al. Acute bleeding after bone marrow transplantation (BMT) – incidence and effect on survival. A quantitative analysis in 1402 patients Blood 1998 91: 1469–1477
Ringdén O, Remberger M, Ruutu T et al. Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan vs total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia Blood 1999 93: 2196–2201
Seber A, Shu XO, Defor T et al. Risk factors for severe hemorrhagic cystitis following BMT Bone Marrow Transplant 1999 23: 35–40
Sencer SF, Haake RJ, Weisdorf DJ . Hemorrhagic cystitis after bone marrow transplantation. Risk factors and complications Transplantation 1993 56: 875–879
Russell SJ, Vowels MR, Vale T . Haemorrhagic cystitis in paediatric bone marrow transplant patients: an association with infective agents, GVHD and prior cyclophosphamide Bone Marrow Transplant 1994 13: 533–539
Chen FE, Liang RHS, Lo JY et al. Treatment of adenovirus-associated haemorrhagic cystitis with ganciclovir Bone Marrow Transplant 1997 20: 997–999
Jurado M, Navarro JM, Hernández J et al. Adenovirus-associated haemorrhagic cystitis after bone marrow transplantation successfully treated with intravenous ribavirin Bone Marrow Transplant 1995 15: 651–652
Mann D, Moreb J, Smith S et al. Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report J Infect 1998 36: 227–228
Hitchcock MJM, Jaffe HS, Martin JC et al. Cidofovir, a new agent with potent anti-herpesvirus activity Antivir Chem Chemother 1996 7: 115–127
Ljungman P, Lambertenghi D, Holler E et al. The use of cidofovir in allogeneic SCT recipients: results of an EBMT retrospective survey Bone Marrow Transplant 1999 23: (Suppl.1) Abstr. EX10
Bogdanovic G, Priftakis P, Taemmeraes B et al. Primary BK virus (BKV) infection due to possible BKV transmission during bone marrow transplantation is not the major cause of hemorrhagic cystitis in transplanted children Pediatr Transplant 1998 2: 288–293
Bogdanovic G, Ljungman P, Wang F et al. Presence of human polyomavirus DNA in the peripheral circulation of bone marrow transplant patients with and without hemorrhagic cystitis Bone Marrow Transplant 1996 17: 573–576
Childs R, Sanchez C, Engler H et al. High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bonemarrow allotransplantation for hematological malignancyfollowing T cell depletion and cyclosporine Bone Marrow Transplant 1998 22: 889–893
Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation J Clin Oncol 1995 13: 1103–1109
Acknowledgements
We express our gratitude to the nursing and medical staff of our BMT unit who cared excellently for our patient.
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Held, T., Biel, S., Nitsche, A. et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant 26, 347–350 (2000). https://doi.org/10.1038/sj.bmt.1702487
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DOI: https://doi.org/10.1038/sj.bmt.1702487
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