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Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir

Abstract

Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects. Bone Marrow Transplantation (2000) 26, 347–350.

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Acknowledgements

We express our gratitude to the nursing and medical staff of our BMT unit who cared excellently for our patient.

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Held, T., Biel, S., Nitsche, A. et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant 26, 347–350 (2000). https://doi.org/10.1038/sj.bmt.1702487

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