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Successful large volume leukapheresis on a small infant allogeneic donor

Bone Marrow Transplantation volume 26, pages 339–341 (2000)Cite this article

Abstract

We successfully performed a hematopoietic stem cell apheresis on the smallest allogeneic donor reported to date, a 6.1 kg female. After placement of a dialysis catheter in the left femoral vein, the COBE Spectra was primed with one unit of paternal whole blood. Heparin and anticoagulant citrate dextrose, solution A (ACD-A) were slowly administered to the patient. Ionized calcium levels were checked hourly and calcium gluconate was given for hypocalcemia. Coagulation parameters were checked throughout the procedure. We collected 4.4 × 106 CD34+ cells/kg (recipient). The donor tolerated the procedure well and was discharged the following day. Five months later, the child manifests no obvious late effects. Bone Marrow Transplantation (2000) 26, 339–341.

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Authors and Affiliations

  1. Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    J Pahys, V Fisher & M Nieder

  2. Department of Transfusion Medicine, Apheresis Service, University Hospitals of Cleveland, Cleveland, Ohio, USA

    M Carneval, R Yomtovian & R Sarode

Authors
  1. J Pahys
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  2. V Fisher
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  3. M Carneval
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  4. R Yomtovian
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  5. R Sarode
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  6. M Nieder
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Pahys, J., Fisher, V., Carneval, M. et al. Successful large volume leukapheresis on a small infant allogeneic donor. Bone Marrow Transplant 26, 339–341 (2000). https://doi.org/10.1038/sj.bmt.1702482

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  • DOI: https://doi.org/10.1038/sj.bmt.1702482

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