Abstract
We report a unique case of brucellosis transmitted by BMT. An 8-year-old boy with the diagnosis of Fanconi's anemia received an allogeneic BMT from his HLA-identical sibling. Routine culture from the infused marrow suspension grew Brucella abortus on day +4 post BMT. Spiking fevers occurred on days +2 and +16. The first febrile episode responded to broad-spectrum antibiotic therapy. However, the second episode did not. B. abortus was isolated from blood cultures taken during the second febrile episode. The Brucella agglutination titer was negative. Antibiotic therapy with oral doxycycline and i.v. gentamycin was successful with no recurrence of infection during 13 months of follow-up. The donor's blood culture was also positive for B. abortus and Brucella antibodies were detectable at 1:320 titer when he presented with fever and hepatosplenomegaly on day +32. We emphasize the need to consider brucellosis in patients undergoing BMT. We suggest that donor and recipient be evaluated for brucellosis especially in countries where the incidence of this infection is relatively high. Bone Marrow Transplantation (2000) 26, 225–226.
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References
Wood EE . Brucellosis as a hazard of blood transfusion Br Med J 1955 1: 27–29
Economidou J, Kalafatas P, Vatopoulou D et al. Brucellosis in two thalassaemic patients infected by blood transfusions from the same donor Acta Haematol 1976 55: 244–249
Naparstek E, Block CS, Slavin S . Transmission of brucellosis by bone marrow transplantation (letter) Lancet 1982 i: 574–575
Ruben B, Band JD, Wong P, Colville J . Person-to-person transmission of Brucella melitensis Lancet 1991 337: 14–15
Hall WH . Modern chemotherapy for brucellosis in humans Rev Infect Dis 1990 12: 1060–1099
Lubani MM, Dudkin KI, Sharda DC et al. A multi-center therapeutic study of 1100 children with brucellosis Pediatr Infect Dis 1989 8: 75–78
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Ertem, M., Kürekçi, A., Aysev, D. et al. Brucellosis transmitted by bone marrow transplantation. Bone Marrow Transplant 26, 225–226 (2000). https://doi.org/10.1038/sj.bmt.1702480
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DOI: https://doi.org/10.1038/sj.bmt.1702480
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