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Mismatched related cord blood transplantation in a severe thalassemia patient

Bone Marrow Transplantation volume 25, pages 1322–1323 (2000)Cite this article

In Southeast Asia, β-thalassemia, and hemoglobin (Hb) E are common. The frequencies of the traits can be as high as 3–9% for β0 thalassemia, and up to 54% or higher for Hb E.1 Patients with β-thalassemia/Hb E can be as severely affected as those with homozygous β-thalassemia or Cooley's anemia. At present, allogeneic hematopoietic stem cell transplantation is the only curative therapy for thalassemia. Issaragrisil et al2 were the first to report successful use of matched related cord blood transplantation (CBT) in a child with β-thalassemia/Hb E disease. In the published literature review, all thalassemic patients treated with CBT received fully matched cord blood (CB).3456 We report our experience of utilizing mismatched CBT in a child with severe β-thalassemia/Hb E disease.

A 3-year-old female was diagnosed with β0-thalassemia/Hb E at 4 months of age when she presented with anemia. Her steady-state hemoglobin level was 7 gm/dl. The result of hemoglobin typing was: Hb F 58.2%, Hb E 41.8%. The patient required packed red blood cell transfusion on three occasions. Her father had β-thalassemia trait and her mother had Hb E trait. Analysis of β globin gene mutation demonstrated a nonsense mutation at codon 17. The patient's HLA typing was: A 2,10; B 62,46; Cw 1,6; Bw 6, −; DR B1* 1502,1401; DR 51,52; DQ A1* 0101,0104; DQ B1* 0501,0502.

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Acknowledgements

We thank Ms Tasanee Mongkolsuk and Ms Kanchana Sujirachato for the excellent HLA laboratory and Ms Watana Chaisiripoomkere for cord blood collection and processing.

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Authors and Affiliations

  1. Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    S Hongeng, S Pakakasama, P Hathirat & C Sangkhapreecha

  2. Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    S Ajjimakorn & A Jaovisidha

  3. Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    P Tardtong

  4. Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    S Jootar

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  1. S Hongeng
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Hongeng, S., Pakakasama, S., Hathirat, P. et al. Mismatched related cord blood transplantation in a severe thalassemia patient. Bone Marrow Transplant 25, 1322–1323 (2000). https://doi.org/10.1038/sj.bmt.1702458

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