Abstract
Prognostic factors in 42 patients aged 11 to 62 (median 46) years, with myelodysplastic syndrome (MDS) or after leukemic transformation, who underwent allogeneic marrow transplantation between 1984 and 1999 were analyzed. Thirty-six had advanced disease morphology; 19 had leukemic transformation. Twenty-nine received a preparative regimen of BuCy2 and 13 busulfan 14 mg/kg, etoposide 50 mg/kg and cyclophosphamide 120 mg/kg. Severe hepatic veno-occlusive disease (VOD) occurred in three patients all of whom received anti-leukemic chemotherapy prior to transplantation. Fifteen patients (36%) died from early transplant-related complications; nine patients relapsed. The estimated 4 year disease-free survival (DFS) was 35% (95% CI 26–44%). Older age was the most significant adverse prognostic factor. Patients with leukemic transformation who underwent early transplantation had significantly better DFS than those treated first with chemotherapy (P = 0.002). Delayed toxicity was rare in these patients; no late relapses occurred. Bone Marrow Transplantation (2000) 25, 1219–1222.
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References
Cheson BD . The myelodysplastic syndromes: current approaches to therapy Ann Intern Med 1990 112: 932–941
Anderson JE, Appelbaum FR, Fisher LD et al. Allogeneic bone marrow transplantation for 93 patients with myelodysplastic syndrome Blood 1993 82: 677–681
Anderson JE, Appelbaum FR, Storb R . An update on allogeneic marrow transplantation for myelodysplastic syndrome Leuk Lymphoma 1995 17: 95–99
Anderson JE, Appelbaum FR, Schoch G et al. Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors Blood 1996 87: 51–58
Ratanatharathorn V, Karanes C, Uberti J et al. Busulfan-based regimens and allogeneic bone marrow transplantation in patients with myelodysplastic syndromes Blood 1993 81: 2194–2199
Anderson JE, Appelbaum FR, Schoch G et al. Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic factors J Clin Oncol 1996 14: 220–226
Locatelli F, Niemeyer C, Angelucci E et al. Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on myelodysplastic syndrome in childhood J Clin Oncol 1997 15: 566–573
Gluckberg H, Storb R, Fefer A et al. Clinical manifestation of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors Transplantation 1974 18: 295–304
Shulman HM, Sale GE, Lerner KG et al. Chronic cutaneous graft-versus-host disease in man Am J Pathol 1978 19: 545–570
McDonald GB, Hinds MS, Fisher LD et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients Ann Intern Med 1993 11: 255–267
Clark JG, Crawford SW, Madtes DK, Sullivan KM . Obstructive lung disease after allogeneic marrow transplantation Ann Intern Med 1989 111: 368–376
Kaplan EL, Meier P . Nonparametric estimation from incomplete observations J Am Stat Assoc 1958 53: 457–481
Mantel N . Evaluation of survival data and two new rank order statistics arising in its consideration Cancer Chemother Rep 1966 50: 163–170
Cox DR . Regression models and life tables J Roy Stat Soc 1972 34: 187–220
Tutschka PJ, Copelan EA, Klein JP . Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen Blood 1987 70: 1382–1388
Storb R, Deeg HJ, Whitehead J et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft-vs-host disease after marrow transplantation for leukemia New Engl J Med 1986 313: 729–735
Nevill TJ, Shepherd JD, Reece DE et al. Treatment of myelodysplastic syndrome with busulfan-cyclophosphamide conditioning followed by allogeneic BMT Bone Marrow Transplant 1992 10: 445–450
O'Donnell MR, Long GD, Parker PM et al. Busulfan/cyclophosphamide as conditioning regimen for allogeneic bone marrow transplantation for myelodysplasia J Clin Oncol 1995 13: 2973–2979
Clift RA, Buckner CD, Thomas ED et al. Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide Blood 1994 84: 2036–2043
Copelan E, Deeg J . Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation Blood 1992 80: 1648–1658
Styler MJ, Crilley P, Biggs J et al. Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective multi-center analysis Bone Marrow Transplant 1999 18: 171–176
Copelan EA, Kapoor N, Berliner M, Tutschka PJ . Bone marrow transplantation without total body irradiation in patients 40 and older Transplantation 1989 48: 65–68
Copelan E, Penza S, Theil K et al. Allogeneic marrow transplantation with BuCy2 in patients with chronic myelogenous leukemia Blood 1998 92: 285a
Blaise D, Maraninchi D, Archimbaud E et al. Allogeneic bone marrow transplantation for acute myeloid leukemia in first remission: a randomized trial of a busulfan-Cytoxan versus Cytoxan-total body irradiation as preparative regimen: a report from the Groupe d'Etudes de la Greffe de Moelle Osseuse Blood 1992 79: 2578–2582
Ringden O, Ruutu T, Remberger M et al. A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplant Group Blood 1994 83: 2723–2730
Copelan EA, Biggs JC, Thompson JM et al. Treatment for acute myelocytic leukemia with allogeneic bone marrow transplantation following preparation with BuCy2 Blood 1991 78: 838–843
Ringden O, Remberger M, Ruutu T et al. for the Nordic Bone Marrow Transplantation Group Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia Blood 1999 93: 2196–2201
Copelan EA . Are busulfan-based preparative regimens equivalent, worse, or better than total body irradiation regimens? In: Bolwell BJ (ed) Current Controversies in Bone Marrow Transplantation Humana Press: Clifton, NJ 2000 pp53–67
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Copelan, E., Penza, S., Elder, P. et al. Analysis of prognostic factors for allogeneic marrow transplantation following busulfan and cyclophosphamide in myelodysplastic syndrome and after leukemic transformation. Bone Marrow Transplant 25, 1219–1222 (2000). https://doi.org/10.1038/sj.bmt.1702432
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DOI: https://doi.org/10.1038/sj.bmt.1702432