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Allografting

A randomised study of allogeneic transplantation with stem cells from blood or bone marrow

Bone Marrow Transplantation volume 25, pages 1129–1136 (2000)Cite this article

Abstract

sixty-one consecutive adult patients with leukaemia, primary myelofibrosis or myelodysplastic syndrome with an hla-identical or one antigen mismatched family donor were randomised to allogeneic transplantation with pbpc or bm. progenitor cells were mobilised into the blood by giving the donors 10 μg/kg/day g-csf subcutaneously for 5–7 days. g-csf was not given to patients after transplantation. the time to neutrophil counts >0.5 × 109/l was 17 days (95% CI 15.2–18.8 days) in the PBPC group compared to 23 (95% CI 20.3–25.7 days) in the BM group (P = 0.0005). the time to platelet counts >20 × 109/l was 13 days (95% CI 11.7–14.3 days) in the PBPC group and 21 days (95% CI 18.7–23.3 days) in the BM group (P = 0.0005). Acute GVHD of grades II–IV developed in six patients transplanted with PBPC and three patients transplanted with BM. The numbers of patients with chronic GVHD were 15 and 8, respectively. Transplant-related mortality and leukaemia-free survival showed no significant differences. Transplantation with PBPC appears preferable for the recipient due to faster neutrophil and platelet recovery. However, the final conclusion can not be drawn before long-term results on chronic GVHD and relapse incidence in longer randomised trials are available. Bone Marrow Transplantation (2000) 25, 1129–1136.

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Acknowledgements

This study was supported by Bergliot and Sigurd Skaugen's ‘Fond til bekjempelse av kreft’. We also thank the nurses at the Bone Marrow Transplant Unit at Rikshospitalet, Oslo for their excellent co-operation, Lill Anny Gunnes Grøseth for CD34+ cell enumeration, and Kaare Osnes for his statistical assistance. Roche Norge AS gave us a significant discount on Neupogen costs during the years 1994–1998.

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Authors and Affiliations

  1. Medical Department, The National Hospital, Oslo, Norway

    D Heldal, G Tjønnfjord, L Brinch & SA Evensen

  2. Department of Surgery B, The National Hospital, Oslo, Norway

    D Albrechtsen

  3. Institute of Immunology, The National Hospital, Oslo, Norway

    T Egeland, R Steen & BG Solheim

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Heldal, D., Tjønnfjord, G., Brinch, L. et al. A randomised study of allogeneic transplantation with stem cells from blood or bone marrow. Bone Marrow Transplant 25, 1129–1136 (2000). https://doi.org/10.1038/sj.bmt.1702422

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