Abstract
Following engraftment of donor hematopoietic cells and induction of host-versus-graft tolerance, immunocompetent lymphocytes of donor origin can induce graft-versus-leukemia (GVL) and graft-versus-tumor (GVT) effects. Engraftment of allogeneic bone marrow cells can be accomplished following non-myeloablative conditioning while possibly controlling graft-versus-host disease (GVHD). GVL and GVT effects may thus be successfully accomplished following non-myeloablative stem cell transplantation (NST) as shown by data derived from experimental animals and man. Bone Marrow Transplantation (2000) 25, Suppl. 25, S54–S57.
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Slavin, S., Or, R., Prighozina, T. et al. Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man. Bone Marrow Transplant 25 (Suppl 2), S54–S57 (2000). https://doi.org/10.1038/sj.bmt.1702356
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DOI: https://doi.org/10.1038/sj.bmt.1702356
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