Abstract
The Welsh Bone Marrow Donor Registry (WBMDR) is in its 11th year of operation and its 4th year as an International ‘Hub’ participating in Bone Marrow Donors Worldwide. It is operated by the Welsh Regional Tissue Typing Laboratory which is accredited by Clinical Pathology Accreditation (UK) Ltd, and the European Federation for Immunogenetics and, together with the Welsh Blood Service, its donor centre, is ISO 9001 Registered. The active donor panel of over 21 000 regular blood donors are all HLA-A, B, DR, DQ typed (over 95% to the split specificity level or higher). All HLA-DR, DQ and over 50% of HLA-A, B typing has been performed by DNA-based methods. CMV antibody status, now tested on all donors, is known on over 70% of subjects. The WBMDR has over 80% success at obtaining Confirmatory Typing samples and operates a rapid Expanded Typing service on stored donor material. It has provided 174 bone marrow donations (140 for UK and 34 for overseas patients), and 11 lymphocyte donations, since its inception in 1989. Bone Marrow Transplantation (2000) 25 , 771–777.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Raffoux C, Marry E, Gebuhrer L . Bone marrow transplantation using voluntary donors. Role of the European Secretariat Nouv Rev Fr Hematol 1991 33: 441–443
Baouz A, Raffoux C . EMDIS European marrow donor information system Comput Meth Prog Biomed 1994 45: 45–46
Darke C, Guttridge MG, Thompson J et al. HLA class I (A, B) and II (DR, DQ) gene and haplotype frequencies in blood donors from Wales Exp Clin Immunogenet 1998 15: 69–83
Bodmer JG, Marsh SGE, Albert ED et al. Nomenclature for factors of the HLA system, 1998 Tissue Antigens 1999 53: 407–446
Fussell H, Darke C . HLA-B7QUINN–A new HLA-B7 variant antigen Eur J Immunogenet 1992 19: 449
Fussell H, Thomas M, Street J et al. Serological identification of a new HLA-B7 variant antigen – HLA-B7QUI Eur J Immunogenet 1994 21: 23–31
Hildebrand WH, Domena JD, Shen SY et al. The HLA-B7Qui antigen is encoded by a subtype of HLA-B27 (B*2708) Tissue Antigens 1994 44: 47–51
Arnett KL, Adams EJ, Gumperz JE et al. Expression of an unusual Bw4 epitope by a subtype of HLA-B8 (B*0802) Tissue Antigens 1995 46: 316–321
Darke C, Fussell H, Street J et al. Serological and molecular identification of an HLA-B8 variant – HLA-B8Jon (B*0802) Exp Clin Immunogenet 1997 13: 139–153
Darke C, Street J, Fussell H et al. A new HLA-B44 variant (B44BO (B*4408)) identified by serology Tissue Antigens 1997 50: 32–37
Guttridge MG, Street J, Thomas M et al. Identification of HLA-A*0224: implications for PCR-SSP HLA typing Tissue Antigens 1999 53: 190–193
Thompson J, Street J, Guttridge MG et al. HLA-A*2502 – frequency and serology of the product Eur J Immunogenet 1998 25: 77
Guttridge MG, Thompson J, Street J et al. Identification, sequencing and serology of HLA-B*3527 Tissue Antigens 1999 53: 383–385
Darke C, Guttridge MG, Street J et al. HLA-B*4703: sequence confirmation, serology and distribution Tissue Antigens 1999 53: 586–590
Darke C, Guttridge MG, Thompson J et al. Molecular, serological and population studies on a novel HLA-B allele – HLA-B*5002 Tissue Antigens 1998 51: 666–670
Young NT, Darke C . Gene frequency and linkage disequilibrium analysis of HLA-DRB1*04 haplotypes in a South Wales population Eur J Immunogenet 1994 21: 15–22
Rees T, Guttridge MG, Street J et al. Identification and distribution of HLA-B*15 alleles in a random population Eur J Immunogenet 1997 24: 36
Thompson J, James D, Street J et al. HLA-A2 alleles in Wales: detection, distribution and serology Eur J Immunogenet 1999 26: 47
Thompson J, Guttridge MG, Darke C . Frequency and linkage disequilibrium with HLA-B of the non-serologically defined HLA-Cw alleles Eur J Immunogenet 1996 23: 78
Darke C, Guttridge MG, Thompson J et al. Frequency and linkage disequilibria of HLA-DRB1, DQB1 and DPB1 alleles in blood donors from Wales Eur J Immunogenet 1999 26: 62
Guttridge MG, Darke C . Rare DRB1 and DQB1 haplotypes identified in 2908 random blood donors Eur J Immunogenet 1996 23: 78
Young NT, Street J, Darke C . Immunoglobulin allotype frequencies in responders and nonresponders to the Rh (D) antigen Exp Clin Immunogenet 1995 12: 88–91
Dorak MT, Owen G, Galbraith I et al. Nature of HLA-associated predisposition to childhood acute lymphoblastic leukemia Leukemia 1995 9: 875–878
Brown MA, Pile KD, Kennedy LG et al. HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom Ann Rheum Dis 1996 55: 268–270
Parkes AB, Darke C, Othman S et al. MHC class II and complement polymorphisms in postpartum thyroiditis Eur J Endocrinol 1996 134: 449–453
Hall FC, Weeks DE, Camilleri JP et al. Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis Quart J Med 1996 89: 821–829
Brown MA, Kennedy LG, Darke C et al. The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis Arth Rheum 1998 41: 460–465
Long CC, Darke C, Marks R . Celtic ancestry, HLA phenotype and increased risk of skin cancer Br J Dermatol 1998 138: 627–630
Dorak MT, Lawson T, Machulla HK et al. Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia Blood 1999 94: 694–700
Groves C J, Howells RD, Williams S et al. Primary standardization for the ELISA of serum thyroperoxidase and thyroglobulin antibodies and their prevalence in a normal Welsh population J Clin Lab Immunol 1990 32: 147–151
Thomas MW, Darke C . Distribution of anti-epithelial cell antibodies in normal blood donors Eur J Immunogenet 1992 19: 453
Thomas MW, Darke C . Subtypes of BFF (BFFa and BFFb) – frequency and linkage disequilibrium with HLA-B and DR alleles Eur J Immunogenet 1992 19: 454
Worwood M, Raha-Chowdhury R, Darke C . Distribution of alleles at D6S105 and D6S265 with possible HLA haplotype associations Tissue Antigens 1994 44: 322–325
Thomas M, Street J, Fussell H et al. Distribution of the HLA-A9 antigen family (A23, A24 and A2403) Tissue Antigens 1996 48: 586–588
Worwood M, Raha-Chowdhury R, Robson KJH et al. The HLA A1-B8 haplotype extends 6Mb beyond HLA-A: associations between HLA-A, B, F and 15 microsatellite markers Tissue Antigens 1997 50: 521–526
Darke C, Winkler S, Guttridge MG et al. Molecular, serological and population studies of the alleles and products of HLA-B*41 Exp Clin Immunogenet 1999 16: 139–149
Sellers J, Thompson J, Guttridge MG et al. Human platelet antigens: typing by PCR using sequence-specific primers and their distribution in blood donors resident in Wales Eur J Immunogenet 1999 26: 393–397
Rees MT, Howells K, McNamara S et al. Profile of Welsh bone marrow donor registry volunteers who have donated bone marrow Eur J Immunogenet 1998 25: 67
Bishara A, Brautbar C, Cohen I et al. Positivity in a modified mixed leukocyte reaction test correlates with molecular HLA-C disparity in prediction of unrelated bone marrow transplantation outcome Hum Immunol 1999 60: 833–839
Nagler A, Brautbar C, Slavin S et al. Bone marrow transplantation using unrelated and family related donors: the impact of HLA-C disparity Bone Marrow Transplant 1996 18: 891–897
Bishara A, Amar A, Brautbar C et al. The putative role of HLA-C recognition in graft versus host disease (GVHD) and graft rejection after unrelated bone marrow transplantation (BMT) Exp Hematol 1995 23: 1667–1675
Tseng LH, Lin MT, Hansen JA et al. Correlation between disparity for the minor histocompatibility antigen HA-1 and the development of acute graft-versus-host disease after allogeneic marrow transplantation Blood 1999 94: 2911–2914
Goulmy E, Schipper R, Pool J et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation New Engl J Med 1996 334: 281–285
Acknowledgements
We thank all the registered panel donors for their continuing support. The Registry owes a considerable debt of gratitude to its actual marrow donors who have selflessly given of their compassion and time in helping to save others. We thank the dedicated staff of the Regional Tissue Typing Laboratory who have worked so ardently to ensure the success of the WBMDR during its first decade. Finally, we are greatly appreciative of the British Bone Marrow Donor Appeal for their continued financial support of the WBMDR's work.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Darke, C. An overview of the Welsh Bone Marrow Donor Registry: 10 years of bone marrow donor provision. Bone Marrow Transplant 25, 771–777 (2000). https://doi.org/10.1038/sj.bmt.1702217
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702217
Keywords
This article is cited by
-
Analysis of the French National Registry of unrelated bone marrow donors, using surnames as a tool for improving geographical localisation of HLA haplotypes
European Journal of Human Genetics (2003)
-
Quality control of a national bone marrow donor registry: results of a pilot study and proposal for a standardized approach
Bone Marrow Transplantation (2003)