Abstract
We prospectively examined stool specimens for enteric viruses in 75 stem cell transplant recipients (autologous 48, allogeneic 27) to determine the frequency and significance of these infections. Only six patients (8%) had a positive isolate. Five of these were allograft recipients (18%) compared to one autograft recipient (2%) (P = 0.02). Unrelated donor BMT recipients were at the highest risk for a viral isolate (OR = 10.5). Adenovirus was the commonest isolate (four patients). One patient each had an echovirus, enterovirus and small round structured virus identified. No correlation was found between the severity of gastro-intestinal symptoms and detection of a viral pathogen. There was no correlation with GVHD or CMV status. The only risk factor identified for isolation of an enterovirus was allogeneic BMT from an unrelated donor. There was a negative correlation with PBSC grafts. All the patients infected with an enteric virus had concomitant infection with other pathogens, compared to only 18% of uninfected patients (P = 0.001). The non-relapse mortality of the infected patients was 50% and only 7% in the uninfected patients (P = 0.01, OR = 12.5), although the isolated virus was the direct cause of death in one patient only. This study indicates a low rate of enteric virus isolation in recipients of PBSC grafts, both autologous and allogeneic. However, unrelated donor BMT is associated with a higher risk of enteric virus infection and an adverse outcome. Bone Marrow Transplantation (2000) 25, 277–282.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shields AF, Hackman RC, Fife KH et al. Adenovirus infections in patients undergoing bone marrow transplantation New Engl J Med 1985 312: 529–533
Flomenberg P, Babbitt J, Drobyski WR et al. Increased incidence of adenovirus disease in bone marrow transplant recipients J Infect Dis 1994 169: 775–781
Blanke C, Clark C, Broun R et al. Evolving pathogens in allogeneic bone marrow transplantation: increased fatal adenoviral infections Am J Med 1995 99: 326–328
Galama J, deLeeuw N, Wittebol S et al. Prolonged enteroviral infection in a patient who developed pericarditis and heart failure after bone marrow transplantation Clin Infect Dis 1996 22: 1004–1008
Biggs DD, Toorkey BC, Carrigan DR et al. Disseminated echovirus infection complicating bone marrow transplantation Am J Med 1990 88: 421–425
Gonzalez Y, Martino R, Badell I et al. Pulmonary enterovirus infections in stem cell transplant recipients Bone Marrow Transplant 1999 23: 511–513
Troussard X, Bauduer F, Gallet E et al. Virus recovery from stools of patients undergoing bone marrow transplantation Bone Marrow Transplant 1993 12: 573–576
Yolken RH, Bishop CA, Townsend TR et al. Infectious gastroenteritis in bone marrow transplant recipients New Engl J Med 1982 306: 1010–1012
Kidd IM, Fox JC, Pillay D et al. Provision of prognostic information in immunocompromised patients by routine application of the polymerase chain reaction for cytomegalovirus Transplantation 1993 56: 867–871
Chakrabarti S, Collingham KE, Fegan C, Milligan DW . Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy Bone Marrow Transplant 1999 23: 1209–1211
Ottinger HD, Beelen DW, Scheulen B et al. Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow Blood 1996 88: 2775–2779
Guillaume T, Rubinstein DB, Symann M . Immune reconstitution and immunotherapy after autologous haematopoietic stem cell transplantation Blood 1998 92: 1471–1490
Hierholzer JC . Adenoviruses in the immunocompromised host Clin Microbiol Rev 1992 5: 262–274
Strickler JG, Singleton TP, Copenhaver CM et al. Adenovirus in the gastrointestinal tract of immunosuppressed patients Am J Clin Pathol 1992 97: 555–558
Hale GA, Heslop HE, Krance RA et al. Adenovirus infections after paediatric bone marrow transplantation Bone Marrow Transplant 1999 23: 277–282
Galama JMD . Enteroviral infections in the immunocompromised host Rev Med Microbiol 1997 8: 33–40
Chrystie IL, Totterdel BM, Banatwala JE . False positive rotazyme tests on faecal samples from babies Lancet 1983 2: 1028
Grohmann GS, Glass RI, Pereira HG et al. Enteric viruses and diarrhea in HIV-infected patients New Engl J Med 1993 329: 14–20
Caul EO . Small round structured viruses: airborne transmission and hospital control Lancet 1994 343: 1240–1241
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chakrabarti, S., Collingham, K., Stevens, R. et al. Isolation of viruses from stools in stem cell transplant recipients: a prospective surveillance study. Bone Marrow Transplant 25, 277–282 (2000). https://doi.org/10.1038/sj.bmt.1702164
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702164
Keywords
This article is cited by
-
A survey on incidence and management of adenovirus infection after allogeneic HSCT
Bone Marrow Transplantation (2019)
-
Infektionen und Immuntherapie
Monatsschrift Kinderheilkunde (2010)
-
GI complications in pediatric patients post-BMT
Bone Marrow Transplantation (2005)
-
Enterovirus infections following T-cell depleted allogeneic transplants in adults
Bone Marrow Transplantation (2004)
-
Infections during mobilizing chemotherapy and following autologous stem cell transplantation
Bone Marrow Transplantation (2001)