Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Central nervous system (CNS) tuberculosis following allogeneic stem cell transplantation

Bone Marrow Transplantation volume 25, pages 567–569 (2000)Cite this article

Abstract

Tuberculosis is an uncommon infectious complication after stem cell transplantation. We report a patient who presented with a brain mass, 3 months after pulmonary tuberculosis had been diagnosed and while he was receiving triple antituberculous therapy. He had extensive chronic GVHD. The diagnosis was made after biopsy of the lesion. The cerebral mass was excised, antituberculous treatment was maintained and the patient made a complete neurologic recovery. Six months later, he died of gram-negative septic shock. Mycobacterial infections should be considered in allograft recipients with chronic GVHD and solid lesions in the brain. Bone Marrow Transplantation (2000) 25, 567–569.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Limon HB . Infections due to Mycobacteria. In: Dale DC (ed) Scientific American Medicine. University of Washington Medical Center: Seattle 1995 pp1–25

    Google Scholar 

  2. Snider D, La Montagne J . The neglected global tuberculosis problem: a report of the 1992 World Congress on Tuberculosis J Infect Dis 1994 169: 1189–1203

    Article  Google Scholar 

  3. Roy V, Weisdorf D . Mycobacterial infections following bone marrow transplantation: a retrospective review of a 20 year experience Blood 1997 19: 460–470

    Google Scholar 

  4. Martino C, Martinez C, Domingo Albás A . Tuberculosis in bone marrow transplant recipients: report of two cases and review of the literature Bone Marrow Transplant 1996 18: 809–812

    CAS  PubMed  Google Scholar 

  5. Openshaw H, Slatkin N . Neurological complications after hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation Blackwell Scientific Publications: Oxford 1998 pp659–673

    Google Scholar 

  6. Parkman R, Weinberg K . Immunological reconstitution following hematopoietic stem cell transplantation. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Stem Cell Transplantation Blackwell Scientific Publications: Oxford 1998 pp 704–711

    Google Scholar 

  7. Shenoy S, Mohanakumar T . Immune reconstitution following allogeneic peripheral blood stem cell transplants Bone Marrow Transplant 1999 23: 335–346

    Article  CAS  Google Scholar 

  8. Hoyle C, Goldman J . Life-threatening infections occurring more than 3 months after BMT Bone Marrow Transplant 1994 14: 247–252

    CAS  PubMed  Google Scholar 

  9. Novari R, Sullivan K . Mycobacterial infections in marrow transplant recipients Transplantation 1983 36: 509–513

    Article  Google Scholar 

  10. Kurzrock R, Zandler A . Mycobacterial pulmonary infections after allogeneic bone marrow transplantation Am J Med 1984 77: 35–40

    Article  CAS  Google Scholar 

  11. Rouleau M, Lenick A . Long term persistence of transferred PPD-reactive T cells after allogeneic bone marrow transplantation Transplantation 1993 55: 72–76

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone Marrow Transplant Unit, Instituto Português de Oncologia, Porto, Portugal

    A Campos, CP Vaz, F Campilho, A Morais & P Pimentel

  2. Department of Microbiology, Instituto Português de Oncologia, Porto, Portugal

    MA Guimarães

  3. Department of Pathology, Instituto Português de Oncologia, Porto, Portugal

    C Lopes

  4. Department of Neurosurgery, Instituto Português de Oncologia, Porto, Portugal

    A Portal

  5. Department of Immuno-Hemotherapy, Instituto Português de Oncologia, Porto, Portugal

    A Carvalhais

Authors
  1. A Campos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. CP Vaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F Campilho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Morais
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. MA Guimarães
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Lopes
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Portal
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A Carvalhais
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P Pimentel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Campos, A., Vaz, C., Campilho, F. et al. Central nervous system (CNS) tuberculosis following allogeneic stem cell transplantation. Bone Marrow Transplant 25, 567–569 (2000). https://doi.org/10.1038/sj.bmt.1702163

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702163

Keywords

This article is cited by

Search

Advanced search

Quick links