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Detailed monitoring of hematopoietic chimerism in a child treated by adoptive immunotherapy for high risk of relapse after BMT for acute myeloid leukemia

Bone Marrow Transplantation volume 25, pages 453–456 (2000)Cite this article

Abstract

We report a case of a 13-year-old boy who was transplanted for relapse of acute myeloid leukemia (AML). A detailed study of hematopoietic chimerism was performed using polymerase chain reaction (PCR) of variable number of tandem repeats (VNTR) at very short time intervals. We used discontinuation of post-transplant immunosuppression and donor lymphocyte infusions (DLI) in order to prevent leukemia relapse that was indicated by a progressive increase in autologous hematopoiesis. Despite the fact that the boy relapsed 10 months after BMT, we could see a significant influence of adoptive immunotherapy on the mixed chimerism status during the post-transplant period. Bone Marrow Transplantation (2000) 25, 453–456.

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Authors and Affiliations

  1. Institute of Hematology and Blood Transfusion, Prague, Czech Republic

    R Formánková, L Honzátková, Z Sieglová & R Brdička

  2. 2nd Department of Pediatrics, 2nd Medical School, Prague, Czech Republic

    R Formánková, J Starý & P Sedláček

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  1. R Formánková
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  2. L Honzátková
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  3. Z Sieglová
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Formánková, R., Honzátková, L., Sieglová, Z. et al. Detailed monitoring of hematopoietic chimerism in a child treated by adoptive immunotherapy for high risk of relapse after BMT for acute myeloid leukemia. Bone Marrow Transplant 25, 453–456 (2000). https://doi.org/10.1038/sj.bmt.1702146

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