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Epstein–Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond–Blackfan anemia

Bone Marrow Transplantation volume 25, pages 209–212 (2000)Cite this article

Abstract

A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 × 107/kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein–Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts. Bone Marrow Transplantation (2000) 25, 209–212.

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Acknowledgements

This work was supported in part by a grant (to S Ohga) from the Ministry of Education, Science and Culture of Japan. We thank Mr Ryu Iwasaki, Miss Noriko Kobayashi (Mitsubishi Kagaku Bio-Clinical Laboratories, Inc. Tokyo) for genetic analyses.

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan

    S Ohga, Y Kanaya, H Maki, H Takada, A Nomura, A Suminoe, A Matsuzaki & T Hara

  2. Department of First Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan

    K Ohshima & M Kanda

  3. Division of Blood Transfusion Service, Graduate School of Medical Sciences, Kyushu University, Japan

    A Nomura

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  1. S Ohga
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Ohga, S., Kanaya, Y., Maki, H. et al. Epstein–Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond–Blackfan anemia. Bone Marrow Transplant 25, 209–212 (2000). https://doi.org/10.1038/sj.bmt.1702138

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