Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Typhlitis complicating autologous blood stem cell transplantation for breast cancer

Bone Marrow Transplantation volume 25, pages 321–326 (2000)Cite this article

Abstract

Three cases of typhlitis occurring during autologous blood stem cell transplantation (ABSCT) for metastatic breast cancer are described. Typhlitis is a rare complication of neutropenia and has uncommonly been reported in the autologous transplant setting. Although it has been most commonly described in children with leukemia, typhlitis has increasingly been reported in adult leukemias and in association with neutropenia secondary to chemotherapy for a number of solid tumors. Only five previous cases of typhlitis in the setting of ABSCT have been described. Whereas diarrhea and fever are common toxicities associated with high-dose chemotherapy, it is likely that many cases of typhlitis go unrecognized. Bone Marrow Transplantation (2000) 25, 321–326.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Wagner ML, Rosenberg HS, Fernbach DJ et al. Typhlitis: a complication of leukemia in childhood Am J Radiol 1970 109: 341–350

    CAS  Google Scholar 

  2. Bajwa RPS, Marwaha RK, Garewal G . Neutropenic enterocolitis and cecal perforation in acute lymphatic leukemia Ind J Cancer 1993 30: 31–33

    CAS  Google Scholar 

  3. Gavan DR, Henry GMA . Colonic complication of acute lymphoblastic leukaemia Br J Rad 1994 67: 449–452

    Article  CAS  Google Scholar 

  4. Katz JA, Wagner ML, Gresik MV et al. Typhlitis: an 18-year experience and post mortem review Cancer 1990 65: 1041–1047

    Article  CAS  Google Scholar 

  5. Paulino AFG, Kennedy R, Norman EN et al. Typhlitis in a patient with acute lymphoblastic leukemia prior to the administration of chemotherapy Am J Ped Hematol Oncol 1994 16: 348–351

    CAS  Google Scholar 

  6. Sherman NJ, Woolley MM . The ileocecal syndrome in acute childhood leukemia Arch Surg 1973 107: 39–42

    Article  CAS  Google Scholar 

  7. Sloas MM, Flynn PM, Kaste SC et al. Typhlitis in cancer: a 30-year experience Clin Infect Dis 1993 17: 484–490

    Article  CAS  Google Scholar 

  8. Hiruki T, Fernandes B, Ramsay J et al. Acute typhlitis in an immunocompromised host: report of an unusual case and review of the literature Dig Dis Sci 1992 37: 1292–1296

    Article  CAS  Google Scholar 

  9. Ikard RW . Neutropenic typhlitis in adults Arch Surg 1981 116: 943–945

    Article  CAS  Google Scholar 

  10. Kies MS, Luedke DW, Boyd JF et al. Neutropenic enterocolitis Cancer 1979 43: 730–734

    Article  CAS  Google Scholar 

  11. Musher DR, Amorosi EL, Gouge T et al. Neutropenic typhlitis simulating carcinoma of the cecum Gastro End 1989 35: 449–451

    Article  CAS  Google Scholar 

  12. Taylor AJ, Dodds WJ, Gonyo JE et al. Typhlitis in adults Gastro Rad 1985 10: 363–369

    Article  CAS  Google Scholar 

  13. Varki AP, Armitage JO, Feagler JR . Typhlitis in acute leukemia, successful treatment by early surgical intervention Cancer 1979 43: 695–697

    Article  CAS  Google Scholar 

  14. Keidan RD, Fanning J, Gatenby RA et al. Recurrent typhlitis: a disease resulting from aggressive chemotherapy Dis Colon Rectum 1989 32: 206–209

    Article  CAS  Google Scholar 

  15. Pestalozzi BC, Sotos GA, Choyke PL et al. Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer Cancer 1993 71: 1797–1800

    Article  CAS  Google Scholar 

  16. Fisherman JS, Cowan KH, Noone M et al. Phase I/II study of 72-hour infusional paclitaxel and doxorubicin with granulocyte colony-stimulating factor in patients with metastaticbreast cancer J Clin Oncol 1996 14: 774–782

    Article  CAS  Google Scholar 

  17. Nagler A, Pavel L, Naparstek E et al. Typhlitis occurring in autologous bone marrow transplantation Bone Marrow Transplant 1992 9: 63–64

    CAS  PubMed  Google Scholar 

  18. Mehta J, Nagler A, Or R et al. Neutropenic entercolitis and intestinal perforation associated with carboplatin-containing conditioning regimen for autologous bone marrow transplantation Acta Oncol 1992 31: 591 (letter)

    Article  Google Scholar 

  19. Or R, Mehta J, Nagler A et al. Neutropenic enterocolitis associated with autologous bone marrow transplantation Bone Marrow Transplant 1992 9: 383–385

    CAS  PubMed  Google Scholar 

  20. Avigan D, Richardson P, Elias A et al. Neutropenic enterocolitis as a complication of high dose chemotherapy with stem cell rescue in patients with solid tumors Cancer 1998 83: 409–414

    Article  CAS  Google Scholar 

  21. Dosik GM, Luna M, Valdivieso M et al. Necrotizing colitis in patients with cancer Am J Med 1979 67: 646–656

    Article  CAS  Google Scholar 

  22. Prolla JC, Kirsner JD . The gastrointestinal lesions and complication of leukemias Ann Int Med 1964 61: 1084–1103

    Article  CAS  Google Scholar 

  23. Asnis DS, Seligman BR, Cohen RI et al. Neutropenic entercolitis: an often unrecognized syndrome J Diarrh Dis Res 1993 11: 252–254

    CAS  Google Scholar 

  24. Millward MJ, Zalcbert J, Bishop JF et al. Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer JCO 1997 15: 750–758

    Article  CAS  Google Scholar 

  25. Pouwels MJM, Donnelly JP, Raemaekers JMM et al. Clostridium septicum sepsis and neutropenic enterocolitis in a patient treated with intensive chemotherapy for acute myeloid leukemia Ann Hematol 1997 74: 143–147

    Article  CAS  Google Scholar 

  26. Curtis BM, Williams DE, Broxmeyer HE et al. Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein Proc Natl Acad Sci USA 1991 88: 5809–5813

    Article  CAS  Google Scholar 

  27. Bukowski RM, Olencki T, Gunn H et al. Phase I trial of subcutaneous interleukin 3 in patients with refractory malignancy: hematological, immunological, and pharmacodynamic findings Clin Cancer Res 1996 2: 347–357

    CAS  PubMed  Google Scholar 

  28. Fischmeister G, Jurz M, Haas OA et al. G-CSF vs GM-CSF for stimulation of peripheral blood progenitor cells (PBPC) and leukocytes in healthy volunteers: comparison of efficacy and tolerability Ann Hematol 1999 78: 117–123

    Article  CAS  Google Scholar 

  29. Patrick CC . Use of flouroquinolones as prophylactic agents in patients with neutropenia Pediatr Infect Dis J 1997 16: 135–139

    Article  CAS  Google Scholar 

  30. Sadullah S, Nagesh K, Johnston D et al. Recurrent septicaemia in a neutropenic patient with typhlitis Clin Lab Haem 1996 18: 215–217

    Article  CAS  Google Scholar 

  31. Kunkel JM, Rosenthal D . Management of the ileocecal syndrome: neutropenic enterocolitis Dis Colon Rectum 1986 29: 196–199

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, The Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL, USA

    L Boggio & JN Winter

  2. Department of Pathology, The Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical Scho, Chicago, IL, USA

    R Pooley & SI Roth

Authors
  1. L Boggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Pooley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. SI Roth
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. JN Winter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boggio, L., Pooley, R., Roth, S. et al. Typhlitis complicating autologous blood stem cell transplantation for breast cancer. Bone Marrow Transplant 25, 321–326 (2000). https://doi.org/10.1038/sj.bmt.1702134

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702134

Keywords

This article is cited by

Search

Advanced search

Quick links