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Chronic Myeloid Leukaemia

Cytogenetic status pre-transplant as a predictor of outcome post bone marrow transplantation for chronic myelogenous leukaemia

Bone Marrow Transplantation volume 25, pages 143–146 (2000)Cite this article

Abstract

We have analysed pre-transplant cytogenetic findings in 418 patients with CML in pre-blastic phase who underwent allogeneic BMT between February 1981 and January 1998. Five different patient groups were identified: A = Philadelphia (Ph)+; B = Ph−, BCR-ABL+; C = variant Ph (VPh); D = Ph chromosome plus at least one of: trisomy 8, +Ph, chromosome 17 abnormalities and E = other abnormalities in addition to the Ph chromosome. There were two principal conclusions. Firstly, Ph− patients showed a better outcome, and VPh patients a worse outcome, than those with a standard Ph, both in terms of leukaemia-free survival (LFS) (76.9%, 22.1% and 31.9%) and the risk of treatment failure relative to those with a standard Ph (relative risks of 0.49 and 1.92, respectively). One contributing factor may be relapse: no Ph− patients relapsed, whereas all other groups showed similar probabilities of relapse at 5 years (range 33.0–44.0%). Secondly, those with the additional changes of +8, +Ph and i(17q) did not show a worse outcome than those with no additional changes (5 year survival of 44.7% vs 51.8%; 5 year LFS of 40.6% vs 31.9%), whereas those with other additional changes may fare worst of all (40.4% and 16.0%, respectively). Bone Marrow Transplantation (2000) 25, 143–146.

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Acknowledgements

This work was supported by the Leukaemia Research Fund.

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  1. Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK

    P Konstantinidou, RM Szydlo, A Chase & JM Goldman

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  1. P Konstantinidou
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  2. RM Szydlo
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  3. A Chase
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  4. JM Goldman
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Konstantinidou, P., Szydlo, R., Chase, A. et al. Cytogenetic status pre-transplant as a predictor of outcome post bone marrow transplantation for chronic myelogenous leukaemia. Bone Marrow Transplant 25, 143–146 (2000). https://doi.org/10.1038/sj.bmt.1702133

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