Abstract
Late onset haemorrhagic cystitis (HC) occurs in 20–30% of allogeneic bone marrow transplant patients. Human polyomavirus BK (BKV) (or less frequently adenovirus) may be involved in the pathogenesis of viral HC and can represent a serious post-transplant complication. Diagnosis and treatment of viral HC can be difficult and has an uncertain outcome. We report the efficacy of sequential vidarabine in the treatment of a patient with severe BKV-associated HC, despite the delay in implementing therapy. Bone Marrow Transplantation (2000) 25, 319–320.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bogdanovic G, Ljungman P, Wang F, Dalianis T . Presence of human polyomavirus DNA in the peripheral circulation of bone marrow transplant patients with and without hemorrhagic cystitis Bone Marrow Transplant 1996 17: 573–576
Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorragic cystitis Bone Marrow Transplant 1994 14: 235–240
Arthur RR, Shah KV, Baust SJ et al. Association of BK viruria with haemorragic cystitis in recipients of bone marrow transplants New Engl J Med 1986 315: 230–234
Shields AF, Hackman RC, Fife KH et al. Adenovirus infections in patients undergoing bone marrow transplantation New Engl J Med 1985 146: 529–533
Kawakami M, Uedas S, Maeda T et al. Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation Bone Marrow Transplant 1997 20: 485–490
Chapman C, Flower AJE, Durrant STS et al. The use of vidarabine in the treatment of human polyomavirus associated acute haemorragic cystitis Bone Marrow Transplant 1991 7: 481–483
Fiala M, Payne JE, Berne TV et al. Role of adenovirus type in hemorragic cystitis secondary to immunosuppression J Urol 1974 112: 595–597
O'Reilly RJ, Lee FK, Grossbard E et al. Papovavirus excretion following marrow transplantation: incidence and association with hepatic dysfunction Transplant Proc 1981 13: 262–266
Granena A, Carreras E, Rozman C et al. Interstitial pneumonitis after BMT: 15 years experience in a single institution Bone Marrow Transplant 1993 11: 453–458
Laszlo D, Bosi A, Guidi S et al. Prostaglandin E2 bladder instillation for the treatment of haemorrhagic cystitis after allogeneic bone marrow transplantation Haematologica 1995 80: 421–425
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vianelli, N., Renga, M., Azzi, A. et al. Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 319–320 (2000). https://doi.org/10.1038/sj.bmt.1702129
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702129
Keywords
This article is cited by
-
Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT
Bone Marrow Transplantation (2008)
-
Cistitis hemorrágica
Revista de Oncología (2003)
-
CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation
Bone Marrow Transplantation (2001)