Patients with hypereosinophilic syndrome (HES) display a very heterogeneous clinical picture ranging from asymptomatic cases to very aggressive forms. We report a 38-year-old woman with progressive HES who developed severe myelofibrosis and was treated by allogeneic stem cell transplantation, using peripheral blood (PBSCT) instead of bone marrow as the source of progenitor cells, after conditioning with cytoxan and busulphan. To the best of our knowledge, this is the first case of HES with myelofibrosis treated with PBSCT. The patient remains alive 8 months post-PBSCT, and bone marrow fibrosis has significantly decreased following transplantation. Bone Marrow Transplantation (2000) 25, 217–218.
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The authors thank Mark Anderson for his technical assistance.
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Vazquez, L., Caballero, D., Del Cañizo, C. et al. Allogeneic peripheral blood cell transplantation for hypereosinophilic syndrome with myelofibrosis. Bone Marrow Transplant 25, 217–218 (2000). https://doi.org/10.1038/sj.bmt.1702102
- hypereosinophilic syndrome
- allogeneic peripheral blood stem cell transplantation
Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome
Bone Marrow Transplantation (2002)