Abstract
It is widely accepted that seroconversion of HBsAg to HBsAb indicates clearance of hepatitis B virus. We describe a 50-year-old man with chronic myelocytic leukemia who developed lethal hepatitis B 22 months after allo-BMT. He had been negative for HBsAg and positive for HBsAb before BMT. Hepatitis B virus latently existing in the liver cells before BMT proliferated during the immunosuppressed period causing fatal hepatitis. Recipients with positive HBsAb should be considered to have the potential for active hepatitis B to emerge after BMT. Bone Marrow Transplantation (2000) 25, 105–108.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McIvor C, Morton J, Bryant A et al. Fatal reactivation of precore mutant hepatitis B virus associated with fibrosing cholestatic hepatitis after bone marrow transplantation Ann Int Med 1994 121: 274–275
Pariente A, Goudeau A, Dubois F et al. Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation Diges Dis Sci 1988 33: 1185–1191
Caselitz M, Hein R, Maschek H et al. Hepatitis B associated liver failure following bone marrow transplantation J Hepatol 1997 27: 572–577
Webster A, Brenner MK, Prentice HG, Griffiths PD . Fatal hepatitis B reactivation after autologous bone marrow transplantation Bone Marrow Transplant 1989 4: 207–208
Martin BA, Rowe JM, Kouides PA et al. Hepatitis B reactivation following allogeneic bone marrow transplantation: case report and review of the literature Bone Marrow Transplant 1995 15: 145–148
Dhédin N, Douvin C, Kuentz M et al. Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation Transplantation 1998 66: 616–619
Uemoto S, Sugiyama K, Marusawa H et al. Transmission of hepatitis B virus core antibody-positive donors in living related liver transplants Transplantation 1998 65: 494–499
Mason A, Xu L, Guo L et al. Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen Hepatology 1998 27: 1736–1742
Brown P . The seroepidemiology of hepatitis A and B in the Asia-Pacific region Asia Pac J Public Health 1987 1: 62–78
Strasser S, McDonald B . Hepatitis viruses and hematopoietic cell transplantation: a guide to patient and donor management Blood 1999 93: 1127–1136
Tchervenkov J, Barkun J, Forbes C et al. Recurrence-free long-term survival after liver transplantation for hepatitis B using interferon-alpha pretransplant and hepatitis B immune globulin posttransplant Ann Surg 1997 226: 356–369
Mertens T, Kock J, Hampl W et al. Reactivated fulminant hepatitis B virus replication after bone marrow transplantation: clinical course and possible treatment with ganciclovir J Hepatol 1996 25: 968–971
Doong L, Tsai H, Schinazi F et al. Inhibition of the replication of hepatitis B virus in vitro by 2′-3′-dideoxy-3′-thiacytidine and related analogues Proc Natl Acad Sci USA 1991 88: 8495–8499
Bartholomew M, Jansen R, Jeffers L et al. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation Lancet 1997 349: 20–22
Acknowledgements
We would like to thank Dr Y Morishima, Dr H Sao and Dr K Kitaori for their BMT procedure.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Iwai, K., Tashi, M., Itoh, M. et al. Fulminant hepatitis B following bone marrow transplantation in an HBsAg-negative, HBsAb-positive recipient; reactivation of dormant virus during the immunosuppressive period. Bone Marrow Transplant 25, 105–108 (2000). https://doi.org/10.1038/sj.bmt.1702093
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702093
Keywords
This article is cited by
-
A prospective trial of vaccine to prevent hepatitis B virus reactivation after hematopoietic stem cell transplantation
Bone Marrow Transplantation (2020)
-
Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation
BMC Infectious Diseases (2019)
-
Risk of hepatitis B surface antigen seroreversion after allogeneic hematopoietic SCT
Bone Marrow Transplantation (2011)
-
Management of Hepatitis B Virus Reactivation in Patients with Hematological Malignancies Treated with Chemotherapy
Infection (2010)
-
Reactivation of resolved hepatitis B virus infection after allogeneic haematopoietic stem cell transplantation
Bone Marrow Transplantation (2004)