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First report of Epstein-Barr virus lymphoproliferative disease after cord blood transplantation

Bone Marrow Transplantation volume 25, pages 120–121 (2000)Cite this article

Epstein–Barr virus-associated lymphoproliferative disease (EBV-LPD) has emerged as a commonly fatal complication of allogeneic bone marrow transplantation (BMT).1 Cord blood (CB) is an alternative source of hematopoietic stem cells for transplantation to treat hematologic disorders.2 We report the first case of EBV-LPD following CB transplantation (CBT).

A 3-year-old girl in second complete remission of pre-B acute lymphoblastic leukemia (ALL) underwent CBT using an unmanipulated unrelated 5/6 HLA matched CB. HLA-DPB1 genotyping was DPB1*0401, DPB1*1101 for recipient and DPB1*0401, DPB1*0501 for donor. The pretransplant conditioning regimen consisted of fractionated total body irradiation (12 Gy) with cyclophosphamide (60 mg/kg i.v. daily on days −5 and −4) and antithymocyte globulin (20 mg/kg daily on days −3 to −1). Cyclosporine in combination with high-dose corticosteroids (methylprednisolone: 5 mg/kg on days 5 to 9, 3 mg/kg on days 10 and 11, then tapered 10% per week and stopped at day 110) was used for graft-versus-host disease (GVHD) prophylaxis. The recipient was EBV seropositive before CBT; the EBV genome was absent from the CB.

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Authors and Affiliations

  1. Service de Pédiatrie, Hôpital de l'Archet, Nice, Cedex 3, 06202, France

    N Sirvent

  2. Laboratoire d'Histocompatibilité, CTS, Marseille, France

    D Reviron

  3. Laboratoire de Virologie et Biologie Moléculaire, Faculté de Médecine, Marseille, France

    X de Lamballerie

  4. Service de Pédiatric et d'Hématologie Pédiatrique, Hôpital de la Timone, Marseille, France

    G Michel

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  1. N Sirvent
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  2. D Reviron
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  4. G Michel
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Sirvent, N., Reviron, D., de Lamballerie, X. et al. First report of Epstein-Barr virus lymphoproliferative disease after cord blood transplantation. Bone Marrow Transplant 25, 120–121 (2000). https://doi.org/10.1038/sj.bmt.1702079

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