Abstract
IT has previously been shown in this laboratory1 that at least two liver factors are necessary for the oxidation of D-ribose-5-phosphate by ammonium sulphate precipitated fractions of horse or rat liver, one being an aldolase and the other a dehydrogenase specific for coenzyme II. Ribose-5-phosphate is oxidized most rapidly by a combination of liver fractions A (0.4–0.5 saturation with ammonium sulphate) and B (0.5–0.6 saturation), the former being richest in glucose-6-phosphate dehydrogenase and the latter most active in splitting ribose-5-phosphate, as judged by the disappearance of pentose using the orcinol method2. The breakdown of ribose-5-phosphate, unlike the oxidation, is independent of coenzyme II and oxygen and never proceeds beyond 66–72 per cent disappearance of pentose.
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References
Dickens, F., and Glock, G. E., Biochem. J., 50, 81 (1951).
Mejbaum, W., Z. physiol. Chem., 258, 117 (1939).
Dische, Z., and Borenfreund, E., J. Biol. Chem., 192, 583 (1951).
Horecker, B. L., and Smyrniotis, P. Z., Archiv. Biochem., 29, 232 (1950) ; J. Biol. Chem., 193, 383 (1951).
Racker, E., Fed. Proc., 7, 180 (1948).
Forrest, R. S., Hough, L., and Jones, J. K. N., Chem. and Indust., 1093 (1951).
Schlenk, F., and Waldvogel, M. J., Archiv. Biochem., 12, 181 (1947). Waldvogel, M. J., and Schlenk, F., ibid., 14, 484 (1947) ; ibid., 22, 185 (1949).
Dische, Z., Naturwiss., 26, 253 (1938) ; 1st Int. Congr. Biochem. (Abstract), 572 (1949).
Kornberg, A., J. Biol. Chem., 182, 805 (1950).
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GLOCK, G. Formation and Breakdown of Pentose Phosphates by Liver Fractions. Nature 170, 162–163 (1952). https://doi.org/10.1038/170162b0
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DOI: https://doi.org/10.1038/170162b0
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