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Epstein–Barr virus-associated B cell lymphoproliferative disease after non-myeloablative allogeneic stem cell transplantation

Bone Marrow Transplantation volume 23, pages 629–630 (1999)Cite this article

Abstract

There is a growing interest in the evaluation of non-myeloablative conditioning therapy for allogeneic stem cell transplantation. Such regimens are expected to produce less toxicity while allowing both engraftment and a graft-versus-disease effect from the large number of donor-derived immunocompetent T lymphocytes given with the stem cells. Heavy immunosuppression used in recipients may have unexpected consequences. We describe the occurrence of a fatal Epstein–Barr virus-associated B cell lymphoproliferative disease (BLPD) early after such a non-myeloablated allogeneic peripheral blood stem cell transplant in a heavily pre-treated patient.

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Authors and Affiliations

  1. Department of Hematology, Centre Hospitalier Universitaire, Nantes, France

    N Milpied, P Moreau & J-L Harousseau

  2. Laboratory of Virology, Centre Hospitalier Universitaire, Nantes, France

    M Coste-Burel

  3. Laboratory of Hematology, Centre Hospitalier Universitaire, Nantes, France

    F Accard & R Garand

  4. Laboratory of Pathology, Centre Hospitalier Universitaire, Nantes, France

    A Moreau

Authors
  1. N Milpied
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  2. M Coste-Burel
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  3. F Accard
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  4. A Moreau
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  5. P Moreau
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  6. R Garand
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  7. J-L Harousseau
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Milpied, N., Coste-Burel, M., Accard, F. et al. Epstein–Barr virus-associated B cell lymphoproliferative disease after non-myeloablative allogeneic stem cell transplantation. Bone Marrow Transplant 23, 629–630 (1999). https://doi.org/10.1038/sj.bmt.1701628

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  • DOI: https://doi.org/10.1038/sj.bmt.1701628

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