Case Report | Published:

Vaginal stenosis following allogeneic bone marrow transplantation for acute myeloid leukaemia

Bone Marrow Transplantation volume 23, pages 523525 (1999) | Download Citation



We report the unusual complication of vaginal stenosis occurring after allogeneic bone marrow transplantation (BMT) for leukaemia. This was in all likelihood a manifestation of chronic graft-versus-host disease (cGVHD), although the patient has no other stigmata of this and suffered little acute graft-versus-host disease (aGVHD) after BMT. Other risk factors for vaginal stenosis were considered and appear to be absent in this patient, although the total body irradiation used as part of her conditioning therapy may play a role. We suggest that vaginal stenosis may be under-reported, since female patients suffer a number of gynaecological complications after BMT, and that regular questioning and examination may aid in making an earlier diagnosis, allowing speedier instigation of therapy and thus improving quality of life.

Author information

Author notes

    • J Treleaven

    Correspondence: Dr JG Treleaven, Department of Haematology, Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK


  1. Department of Haematology, The Royal Marsden NHS Trust, Sutton, UK

    • C DeLord
    • , J Treleaven
    •  & R Saso
  2. Department of Medical Oncology, The Royal Marsden NHS Trust, Sutton, UK

    • R L Powles
  3. Department of Gynaecology, The Royal Marsden NHS Trust, Sutton, UK

    • J Shepherd


  1. Search for C DeLord in:

  2. Search for J Treleaven in:

  3. Search for J Shepherd in:

  4. Search for R Saso in:

  5. Search for R L Powles in:

About this article

Publication history