Original Article

Ifosfamide and etoposide-based chemotherapy as salvage and mobilizing regimens for poor prognosis lymphoma

  • Bone Marrow Transplantation volume 23, pages 413419 (1999)
  • doi:10.1038/sj.bmt.1701592
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Abstract

We treated 40 patients with poor prognosis lymphomas. Patients with non-Hodgkin’s lymphoma (NHL, n = 14) received MINE chemotherapy (mesna, ifosfamide 1330 mg/m2 and etoposide 65 mg/m2 by i.v. infusions on days 1–3, mitoxantrone 8 mg/m2 i.v. on day 1), and those with Hodgkin’s disease (HD, n = 26) received VIM chemotherapy (mesna, ifosfamide 1200 mg/m2 by i.v. infusion on days 1–5, etoposide 90 mg/m2 by i.v. infusion on days 1, 3 and 5, and methotrexate 30 mg/m2 i.v. on days 1 and 5). Chemotherapy was followed by G-CSF (10 or 16 μg/kg in two divided doses daily) to mobilize PBSC. We performed 134 aphereses (median three leukaphereses per patient) starting on either day 13 (median; VIM) or day 12 (median; MINE). The median yield was 9.9 × 106 CD34+ cells/kg and 53.2 × 104 CFU-GM/kg for VIM, and 13.5 × 106 CD34+ cells/kg and 53.4 × 104 CFU-GM/kg for MINE. Except for predictable myelosuppression, no serious toxicity was seen. Response rate using MINE was 63% (18% CR, 45% PR) and using VIM 50% (17% CR, 33% PR). We conclude that VIM and MINE are effective and well-tolerated salvage regimens in patients with lymphomas and, followed by G-CSF, they also exhibit good capacity to mobilize stem cells in a predictable time interval.

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Author notes

    • J Mayer

    Correspondence: J Mayer, Department of Internal Medicine – Hematooncology, Masaryk University Hospital, Brno, Jihlavska 20, 639 00, Czech Republic

Affiliations

  1. Department of Internal Medicine – Hematooncology, Masaryk University Hospital, Brno, Czech Republic

    • J Mayer
    • , Z Kořístek
    • , I Vášová
    •  & J Vorlιček
  2. Department of Radiotherapeutic Medicine, Faculty Hospital, Ostrava, Czech Republic

    • P Vodvářka

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