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HBeAg-negative hepatitis B in a previously thalassemic patient during immunosuppressive therapy for chronic GVHD

Bone Marrow Transplantation volume 22, pages 919–921 (1998)Cite this article

Abstract

We report the case of a 15-year-old previously thalassemic girl who, 15 months after allogeneic BMT, developed HBeAg-negative hepatitis B (variant with mu-1896). In the absence of another route of transmission, HBV reactivation is postulated. The time of emergence of the HBV variant (with mu-1896) is probably related to the development of anti-HBe immunity. This mutant strain is associated with fulminant hepatitis. The patient achieved complete remission and HBV eradication despite having moderate GVHD and receiving immunosuppressive therapy.

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Authors and Affiliations

  1. First Department of Pediatrics, Aghia Sophia Children’s Hospital, University of Athens, Greece

    S Kostaridou, V Ladis & A Kattamis

  2. Academic Department of Medicine, Hippokration General Hospital, Athens, Greece

    A Laras & SJ Hadziyannis

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  1. S Kostaridou
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  2. V Ladis
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  3. A Kattamis
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  4. A Laras
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  5. SJ Hadziyannis
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Kostaridou, S., Ladis, V., Kattamis, A. et al. HBeAg-negative hepatitis B in a previously thalassemic patient during immunosuppressive therapy for chronic GVHD. Bone Marrow Transplant 22, 919–921 (1998). https://doi.org/10.1038/sj.bmt.1701433

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  • DOI: https://doi.org/10.1038/sj.bmt.1701433

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