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Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population

Bone Marrow Transplantation volume 22, pages 587–589 (1998)Cite this article

Abstract

Over a 3-month period, four patients who had received unrelated donor (UD) bone marrow transplants (BMT) presented with severe mucocutaneous herpes simplex virus (HSV) infection while receiving acyclovir (ACV) prophylaxis. Sensitivity testing of the isolates revealed three to be acyclovir-resistant and in one patient the infection was also characterised by a marked failure to respond to foscarnet (phosphonoformic acid). The emergence of ACV-resistant HSV infections in themselves is a new and challenging problem, and yet a far greater problem will become evident if these infections develop resistance to non thymidine kinase dependent therapy.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, University of Bristol, Bristol, UK

    JM Darville

  2. Public Health Laboratory, Bristol, UK

    JM Darville & APCH Roome

  3. Department of Paediatric Oncology, Bristol Royal Hospital for Sick Children, Bristol, UK

    BE Ley & ABM Foot

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  1. JM Darville
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  2. BE Ley
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  3. APCH Roome
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  4. ABM Foot
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Darville, J., Ley, B., Roome, A. et al. Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population. Bone Marrow Transplant 22, 587–589 (1998). https://doi.org/10.1038/sj.bmt.1701392

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  • DOI: https://doi.org/10.1038/sj.bmt.1701392

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