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Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

Bone Marrow Transplantation volume 22, pages 303–305 (1998)Cite this article

Abstract

Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted >22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

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Authors and Affiliations

  1. Division of Hematologic Malignancies, Bone Marrow Transplantation Program, Johns Hopkins Oncology Center, Baltimore, MD, USA

    EJ Fuchs, A Seber, V Altomonte, HG Braine, RL Humphrey, RJ Jones, SJ Noga, K Schepers, SK Wright & GB Vogelsang

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  1. EJ Fuchs
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  2. A Seber
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  3. V Altomonte
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  4. HG Braine
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  5. RL Humphrey
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  6. RJ Jones
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  7. SJ Noga
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  8. K Schepers
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  9. SK Wright
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  10. GB Vogelsang
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Fuchs, E., Seber, A., Altomonte, V. et al. Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions. Bone Marrow Transplant 22, 303–305 (1998). https://doi.org/10.1038/sj.bmt.1701323

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  • DOI: https://doi.org/10.1038/sj.bmt.1701323

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