Abstract
Relapse of chronic myeloid leukemia (CML) as extramedullary granulocytic sarcoma (GS) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. We report two patients who developed spinal GS as the first indication of relapse after allogeneic BMT for CML. In both cases, the marrow was in morphologic and karyotypic remission. However, fluorescence in situ hybridization (FISH) successfully demonstrated the presence of a minor Ph-positive clone in the marrow, as well as an occult clone with an additional Ph chromosome detected in one case. The results indicated a stronger graft-versus-leukemia effect in the marrow than in the peripheral tissues.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Au, W., Chan, A., Lie, A. et al. Isolated extramedullary relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant 22, 99–102 (1998). https://doi.org/10.1038/sj.bmt.1701294
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701294
Keywords
This article is cited by
-
Tyrosine kinase inhibitor STI571 in the treatment of Philadelphia chromosome-positive leukaemia failing myeloablative stem cell transplantation
Bone Marrow Transplantation (2002)
-
Glucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation
Bone Marrow Transplantation (2002)
-
Extramedullary relapse after allogeneic bone marrow transplantation for haematological malignancy
Bone Marrow Transplantation (2000)