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Donor leukocyte infusion for treatment of graft rejection post partially mismatched related donor bone marrow transplant

Bone Marrow Transplantation volume 22, pages 111–113 (1998)Cite this article

Abstract

Graft rejection following bone marrow transplantation is more common in patients who receive their grafts from alternative donors and whose marrow is T cell depleted. Rejection in these patients is mediated by persistent host cells that interfere with successful establishment of donor-derived hematopoietic recovery. We describe a patient with chronic myelogenous leukemia in accelerated phase who rejected a T cell-depleted bone marrow graft, 2 months following partially mismatched related donor bone marrow transplant. Unmanipulated peripheral blood donor leukocyte infusion, without additional chemotherapy or immunosuppressive therapy resulted in complete hematopoietic recovery. Cytogenetics and RFLP demonstrated hematopoietic donor chimerism. The patient did not develop graft-versus-host disease.

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Authors and Affiliations

  1. The Division of Transplantation Medicine of the University of South Carolina School of Medicine, Department of Medicine, Richland Memorial Hospital, Columbia, SC, USA

    KT Godder, SH Abhyankar, LS Lamb, SS Geier, AR Pati, AP Gee & PJ Henslee-Downey

  2. The Division of Transplantation Medicine of the University of South Carolina School of Medicine, Department of Pediatrics, Richland Memorial Hospital, Columbia, SC, USA

    KT Godder, SH Abhyankar & PJ Henslee-Downey

  3. The Division of Transplantation Medicine of the University of South Carolina School of Medicine, Center for Cancer Treatment and Research, Richland Memorial Hospital, Columbia, SC, USA

    KT Godder, SH Abhyankar, AR Pati & PJ Henslee-Downey

  4. Division of Genetics, Department of Obstetrics and Gynecology, Columbia, SC, USA

    RG Best

  5. Department of Microbiology and Immunology Richland Memorial Hospital, The Division of Transplantation Medicine of the University of South Carolina School of Medicine, Columbia, SC, USA

    SS Geier & AP Gee

Authors
  1. KT Godder
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  2. SH Abhyankar
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  3. LS Lamb
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  4. RG Best
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  5. SS Geier
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  6. AR Pati
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  7. AP Gee
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  8. PJ Henslee-Downey
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Godder, K., Abhyankar, S., Lamb, L. et al. Donor leukocyte infusion for treatment of graft rejection post partially mismatched related donor bone marrow transplant. Bone Marrow Transplant 22, 111–113 (1998). https://doi.org/10.1038/sj.bmt.1701278

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  • DOI: https://doi.org/10.1038/sj.bmt.1701278

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