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Conditioning Regimens

Outpatient total body irradiation prior to bone marrow transplantation in pediatric patients: a feasibility analysis

Bone Marrow Transplantation volume 21, pages 651–652 (1998)Cite this article

Abstract

Outpatient total body irradiation (TBI) prior to bone marrow transplantation has been accomplished in a total of 68 pediatric patients. The TBI regimen was fractionated with a total dose of 12 Gy in eight fractions twice daily. Antiemetic therapy consisted of oral ondansetron three times daily throughout the TBI course. Eight patients experienced mild nausea without vomiting, and four patients experienced mild nausea and vomiting. One patient required intravenous hydration after severe nausea and vomiting. Another patient experienced intractable diarrhea and dehydration which required inpatient management. Outpatient TBI prior to bone marrow transplantation is feasible in pediatric patients.

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Authors and Affiliations

  1. Department of Radiology, Division of Radiation Oncology, Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, IL, USA

    GL Applegate, BB Mittal, P Johnson & MH Marymont

  2. Department of Hematology and Oncology, Children’s Memorial Hospital and Northwestern University Medical School, Chicago, IL, USA

    M Kletzel, E Morgan & K Danner

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  1. GL Applegate
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  2. BB Mittal
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  3. M Kletzel
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  4. E Morgan
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  5. P Johnson
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  6. K Danner
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  7. MH Marymont
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Applegate, G., Mittal, B., Kletzel, M. et al. Outpatient total body irradiation prior to bone marrow transplantation in pediatric patients: a feasibility analysis. Bone Marrow Transplant 21, 651–652 (1998). https://doi.org/10.1038/sj.bmt.1701149

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  • DOI: https://doi.org/10.1038/sj.bmt.1701149

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