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Hyperleukocytosis and retinal hemorrhages after chemotherapy and filgrastim administration for peripheral blood progenitor cell mobilization

Bone Marrow Transplantation volume 21, pages 835–837 (1998)Cite this article

Abstract

A 49-year-old man with mantle cell lymphoma received 2.5 g/m2 of cyclophosphamide and 900 mg/m2 of etoposide followed by 10 μg/kg/day of Filgrastim for PBPC mobilization. This was complicated by marked hyperleukocytosis and retinal hemorrhages. The patient’s symptoms improved gradually following leukopheresis. To the best of our knowledge, this is the first report describing this complication in patients undergoing PBPC mobilization. Early recognition of symptoms is important in order to stop Filgrastim and initiate immediate leukapheresis.

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Authors and Affiliations

  1. Department of Internal Medicine, Section of Medical Oncology, Yale Cancer Center, New Haven, CT, USA

    E Salloum & DL Cooper

  2. Department of Ophthalmology, Yale University School of Medicine, Yale Cancer Center, New Haven, CT, USA

    KM Stoessel

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  1. E Salloum
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  2. KM Stoessel
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  3. DL Cooper
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Salloum, E., Stoessel, K. & Cooper, D. Hyperleukocytosis and retinal hemorrhages after chemotherapy and filgrastim administration for peripheral blood progenitor cell mobilization. Bone Marrow Transplant 21, 835–837 (1998). https://doi.org/10.1038/sj.bmt.1701090

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  • DOI: https://doi.org/10.1038/sj.bmt.1701090

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