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Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506

Abstract

Two patients with CsA-associated neurotoxicity developed severe cerebellar swelling and thrombotic thrombocytopenic purpura after switching to FK506 and high-dose corticosteroids. The prodrome of CsA-associated neurotoxicity, TTP and hypertension while receiving FK506, and high-dose corticosteroids could all be implicated in the development of this syndrome. Close monitoring of patients receiving FK506 and high-dose corticosteroids, for the development of TTP is warranted. Early radiological examination should also be considered in such patients to allow early surgical intervention.

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Tezcan, H., Zimmer, W., Fenstermaker, R. et al. Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. Bone Marrow Transplant 21, 105–109 (1998). https://doi.org/10.1038/sj.bmt.1701047

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Keywords

  • cerebellar swelling
  • TTP
  • FK506
  • cyclosporine neurotoxicity
  • steroids

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