Abstract
Acute graft-versus-host disease (aGVHD) remains a major barrier to a wider application of allogeneic bone marrow transplantation (BMT). Although this complication is mainly dependent on donor-derived T lymphocytes, very little information is available concerning the mechanism of lethality. In this study, we investigated both the expression of Fas/Fas-ligand (FasL) and lymphocyte subset reconstitution in patients who underwent HLA-matched related allogeneic BMT (n = 16) and normal donors (n = 10), and several distinct features were observed. First, the reconstitutions of CD3+ and CD56+ cells were different between the aGVHD+ and aGVHD− group. In particular, the percentage of CD3−CD56+ cells was significantly decreased in patients with aGVHD (P < 0.01). second, the expansion of cd8+ (P = 0.01) and CD8+ CD28− T cells (P = 0.03) was a characteristic finding in patients with aGVHD. Finally, we found that the percentages of Fas+CD8+, Fas+HLA-DR+ and FasL+ CD8+ cells were significantly increased. Fas antigen was highly coexpressed on most of the lymphocyte subsets, especially on CD8+ cells (P < 0.01), and also, significantly higher coexpression of fasl on cd8+ cells was found in patients with aGVHD (P < 0.01). in summary, an increase in the percentage of cd8+ cells which express Fas and its ligand in patients with aGVHD after BMT points to a possible role for the Fas/FasL pathway in the effector phase of aGVHD.
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Lee, S., Chong, S., Lee, J. et al. Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD. Bone Marrow Transplant 20, 883–888 (1997). https://doi.org/10.1038/sj.bmt.1700986
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DOI: https://doi.org/10.1038/sj.bmt.1700986
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