Unsuccessful CTL transfusion in a case of post-BMT Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD)

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Abstract

A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferating LPD using chemotherapy (VP16/dexa- methasone) followed by two doses of EBV-specific CTL and one dose of unstimulated donor leukocytes were not successful. We assume delay of infusions (day +100, +107) and insufficient CTL cell doses (total 9.2 × 106) may have been responsible for the poor outcome in this case.

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Imashuku, S., Goto, T., Matsumura, T. et al. Unsuccessful CTL transfusion in a case of post-BMT Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD). Bone Marrow Transplant 20, 337–340 (1997) doi:10.1038/sj.bmt.1700883

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Keywords

  • bone marrow transplantation
  • Epstein–Barr virus-associated lymphoproliferative disorder
  • cytotoxic T-lymphocyte

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