Abstract
A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Oshima, Y., Takahashi, S., Nagayama, H. et al. Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow Transplant 19, 737–740 (1997). https://doi.org/10.1038/sj.bmt.1700731
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700731
Keywords
This article is cited by
-
Clinical Characteristics of Myositis Associated with Graft-Versus-Host Disease
Current Rheumatology Reports (2021)
-
Immunohistochemistry of affected tissue may guide cGVHD treatment decisions
Bone Marrow Transplantation (2012)
-
Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia: report of a case and review of literature
Clinical Rheumatology (2007)
-
Foreign cells in polymyositis: Could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?
Current Rheumatology Reports (2003)