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Malignant hyperthermia induced by general anesthesia for bone marrow harvesting


We present a case of a bone marrow donor who developed rhabdomyolysis, acute renal failure and pulmonary edema following an apparently uneventful general anesthesia for bone marrow harvesting. Because malignant hyperthermia (MH) was suspected, he was treated with dantrolene, fluid loading, and continuous hemodiafiltration along with symptomatic supportive care. He made a full recovery and was discharged 3 weeks after harvest. Although the incidence of MH is low, marrow donation involves the risks of anesthesia as is seen in this case. Close monitoring is required to prevent life-threatening complications associated with the bone marrow harvesting procedure.

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Hosoya, N., Miyagawa, K., Mimura, T. et al. Malignant hyperthermia induced by general anesthesia for bone marrow harvesting. Bone Marrow Transplant 19, 509–511 (1997).

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  • bone marrow donor
  • complications
  • general anesthesia
  • malignant hyperthermia
  • rhabdomyolysis
  • acute renal failure


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