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Infections Post Transplant

Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin

Bone Marrow Transplantation volume 19, pages 43–47 (1997)Cite this article

Abstract

Aspergillus infections in pediatric bone marrow transplant (BMT) patients are usually fatal. We began the use of a prophylactic nasal spray of amphotericin in 1990. This nasal spray was provided in addition to low-dose intravenous amphotericin. During the time of this study, the number of fatal cases of aspergillus in the pediatric BMT population was reduced significantly from 13.8% to 1.8% (P < 0.0025) thereby suggesting that the use of nasal amphotericin in this population helps to prevent fatal aspergillus infections. the lack of significant side-effects and the ease of administration make this a very helpful preventive measure in the supportive care of pediatric bone marrow transplant patients.

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Authors and Affiliations

  1. Department of Pediatrics, Pediatric Bone Marrow Transplant Program, The University of Iowa, Iowa City, IA, USA

    ME Trigg, H Kook, SL Rumelhart & MD Holida

  2. Pharmacy Department, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    D Morgan

  3. Department of Preventive Medicine and Environmental Health, The University of Iowa, Iowa City, IA, USA

    TL Burns

  4. University of Colorado School of Medicine, Denver, CO, USA

    RH Giller

Authors
  1. ME Trigg
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  2. D Morgan
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  3. TL Burns
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  4. H Kook
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  5. SL Rumelhart
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  6. MD Holida
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  7. RH Giller
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Trigg, M., Morgan, D., Burns, T. et al. Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin. Bone Marrow Transplant 19, 43–47 (1997). https://doi.org/10.1038/sj.bmt.1700618

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  • DOI: https://doi.org/10.1038/sj.bmt.1700618

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