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Cytochrome c and in vitro Formation of Bile Pigments


THIS communication describes the attempted in vitro conversion of cytochrome c to bile pigments, using coupled oxidation with ascorbic acid1, and forms part of a systematic study of the relationship of chemical structure to bile pigment formation2,3.

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  1. Lemberg, R., Legge, J. W., and Lockwood, W. H., Biochem. J., 32, 1715 (1938).

    Google Scholar 

  2. Gardikas, C., Kench, J. E., and Wilkinson, J. F., Biochem. J., 46, 85 (1950).

    Article  CAS  Google Scholar 

  3. Kench, J. E., Gardikas, C., and Wilkinson, J. F., Biochem. J., 47, 129 (1950).

    Article  CAS  Google Scholar 

  4. Theorell, H., and Åkesson, Å., J Amer. Chem. Soc., 63, 1820 (1941).

    Article  CAS  Google Scholar 

  5. Paul, K.-G., Acta Chem. Scand., 5, 389 (1951).

    Article  CAS  Google Scholar 

  6. Bigwood, E. J., and Thomas, J., C.R. Soc. Biol., 117, 220 (1940).

    Google Scholar 

  7. Lemberg, R., and Wyndham, R. A., J. Proc. Roy. Soc., N.S.Wales, 70, 343 (1937).

    CAS  Google Scholar 

  8. Keilin, D., and Hartree, E. F., Biochem. J., 39, 289 (1945).

    Article  CAS  Google Scholar 

  9. Bonnichsen, R. K., Acta Chem. Scand., 2, 561 (1948).

    Article  CAS  Google Scholar 

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GARDIKAS, C., KENCH, J. Cytochrome c and in vitro Formation of Bile Pigments. Nature 169, 969–970 (1952).

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