Use of Unweaned White Mice in Foot-and-Mouth Disease Research

Abstract

IT is now two years since it was found that an acute clinical infection could be readily produced by foot-and-mouth disease virus when inoculated intraperitoneally into mice one week old. A summary of the first year's work was published a year ago¹. We have continued to use large numbers of unweaned mice in our work and we have encouraged their use in other institutes engaged on foot-and-mouth disease research. The early indications that we had of the value of this animal have been fully confirmed, and corroborative reports are now being received from other workers. It would be appropriate, therefore, to summarize some of our more recent findings.