Letter | Published:

Release of Histamine from Rat Diaphragm by Cobra Venom

Naturevolume 169pages10641065 (1952) | Download Citation



SEVERAL substances like strychnine, adrenaline and curare alkaloids are known to set free histamine from skeletal muscle. The release of histamine from rat diaphragm by ammonia1 and B-tubo-curarine chloride2 has recently been reported. Feldberg and Kellaway3 have shown that snake poisons liberate histamine from the perfused lungs of guinea pigs and cats. The experiments described here demonstrate that cobra (Naia naia) venom is a potent liberator of histamine from striated muscle of the rat.

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  1. 1

    Schild, H. O., Nature, 164, 24 (1949).

  2. 2

    Rocha e Silva and Schild, H. O., J. Physiol., 109, 448 (1949).

  3. 3

    Feldberg, W., and Kellaway, C. H., J. Physiol., 90, 257 (1937).

  4. 4

    Chopra, R. N., and Chowhan, J. S., Ind. Med. Gaz., 74, 422 (1939).

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  1. Haffkine Institute, Bombay, 12

    • N. K. DUTTA
    •  & K. G. A. NARAYANAN


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