Letter | Published:

Observations on the Connexion between Intermedin and Adrenocorticotropic Hormone

Naturevolume 169page1061 (1952) | Download Citation



IN a communication which has recently appeared under the above title, Johnsson and Högberg1 have claimed that intermedin and adrenocorticotropic hormone (ACTH) are closely related or identical. Moreover, they have suggested that the assay for melanophore-expansion activity in the frog is “a rapid and simple method of testing for adrenocorticotropic hormone”. Similar conclusions have been arrived at independently by Sulman2. Experimental evidence which we have obtained relating to this question does not support these claims.

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  1. 1

    Johnsson, S., and Högberg, B., Nature, 169, 286 (1952).

  2. 2

    Sulman, F. G., Refuah Veter. (Israel), 9, 31 (1952); Nature, 169, 588 (1952).

  3. 3

    Li, C. H., J. Amer. Chem. Soc., 74, 2124 (1952).

  4. 4

    Sayers, M. A., Sayers, G., and Woodbury, L. A., Endocrin., 42, 379 (1948).

  5. 5

    Stehle, R. L., J. Pharmacol. Exp. Therap., 57, 1 (1936).

  6. 6

    Geschwind, I. I., Porath, J. O., and Li, C. H., J. Amer. Chem. Soc., 74, 2121 (1952).

  7. 7

    Kunkel, H. G., and Tiselius, A., J. Gen. Physiol., 35, 118 (1951).

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  1. Department of Biochemistry and Division of Anatomy, University of California, Berkeley, California

    •  & CHOH HAO LI


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