Letter | Published:

Toxicity of Aureomycin to Guinea Pigs

Naturevolume 169page1014 (1952) | Download Citation



SINCE the original studies of Stokstad and co-workers1, the growth-promoting effect of aureomycin has been established with several species of animals. So far as we know there are, however, no reports about the effect of aureomycin on guinea pigs. We have used aureomycin in investigations dealing with the synthesis of vitamins in the intestines of rats and guinea pigs. In these experiments it was found that the effect of aureomycin on guinea pigs is quite different from that observed with rats. The same proportional dose which has had a growth-promoting effect on rats appears to be very toxic to guinea pigs.

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    Stokstad, Jukes, Pierce, Page and Franklin, J. Biol. Chem., 180, 647 (1949). Stokstad and Jukes, Proc. Soc. Exp. Biol. Med., 73, 523 (1950).

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    Harned et al., Ann. N.Y. Acad. Sci., 51, 182 (1948); ref.: Loomis, Science, 111, 474 (1950).

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    Colby, Rau and Dunn, Proc. Soc. Exp. Biol. Med., 75, 234 (1950).

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    Bell, Whitehair and Gallup, Proc. Soc. Exp. Biol. Med., 76, 284 (1951).

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    Stanley, Schweinburg and Rutenburg, Proc. Soc. Exp. Biol. Med., 78, 121 (1951).

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    Stuart and Slavin, Nature, 167, 319 (1951).

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    Loomis, Science, 111, 474 (1950).

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  1. Department of Nutritional Chemistry, University of Helsinki



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