Letter | Published:

New Derivatives of Nitroparaffins and their Antitubercular and Antirickettsial Properties

Naturevolume 168pages562563 (1951) | Download Citation


  • An Erratum to this article was published on 08 December 1951


AS I have indicated earlier, the reaction of nitroparaffins with formaldehyde and ammonia or amines may lead to the formation of polymers1. Further experiments have shown2 that a number of new ring compounds of 1 : 3-tetrahydro-oxazine (I and II) and 1-oxa-3-aza-cyclooctane (III) type are formed by the interaction of 1-nitropropane with formaldehyde and ammonia. The products can be transformed into hydrochlorides of the open-chain amines (IV), (V), (VI) or methiodide (VII). 2-Nitropropane yields the amine (VIII)3 with formaldehyde and ammonia.


  1. 1

    Urbański, T., U.S. Pat. 2,419,043 (1947); Brit. Pat. 601,101 (1948). Urbański, T., and Poole, H. J., Brit. Pat. 616,337 (1949).

  2. 2

    Hirst, E. L., Jones, J. K. N., Minahan, S., Ochyński, F. W., Thomas, A. T., and Urbański, T., J. Chem. Soc., 924 (1947).

  3. 3

    Jones, J. K. N., and Urbański, T., J. Chem. Soc., 1766 (1949).

  4. 4

    Urbański, T., and Lipska, Mrs. E., Roczniki Chemii (in the press).

  5. 5

    Urbański, T., and Szczepanik, Mrs. M., Roczniki Chemii, (in the press).

  6. 6

    Ochyński, F. W., Thomas, A. T., and Urbański, T., unpublished work (cf. Senkus, U.S. Pat. 2,447,822; 1948).

  7. 7

    Slopek, S., personal communications (January 26 and April 2, 1951).

  8. 8

    Venulet, J., personal communication (January 26, 1951).

  9. 9

    Slopek, S., and Rożniecka, Miss D., personal communication (January 26, 1951).

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  1. Department of Chemistry, Institute of Technology, Warsaw

  2. Institute of Tuberculosis, Warsaw



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