Letter | Published:

Direct Oxidation of Glucose by Aerobacter sp.

Naturevolume 168pages515516 (1951) | Download Citation



A PRECISE picture of a pathway of glucose metabolism existing in addition to the classical scheme proposed by Embden, Meyerhof, Parnas, Cori and many others is slowly emerging from experiments on carbohydrate metabolism1–7. This route, proceeding by way of 6-phosphogluconate and its derivatives, is called ‘direct’. Some years ago, a study of aerobic and anaerobic acid formation with nitrogen-poor bacteria led one of us (J. D. L.) to suppose that, beside the classical respiration by triose phosphate dehydrogenase, our strain could equally well oxidize glucose by way of phosphogluconate, gluconate or a non-phosphorylative process8.

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  1. 1

    Warburg, O., Christian, W., and Griese, A., Biochem. Z., 282, 157 (1935). Warburg, O., and Christian, W., Biochem. Z., 287, 440 (1936); 292, 287 (1937).

  2. 2

    Lipmann, F., Nature, 138, 588 (1936).

  3. 3

    Dickens, F., Nature, 138, 1057 (1936); Biochem. J., 32, 1626 (1938).

  4. 4

    Dickens, F., and Glock, G. E., Nature, 166, 33 (1950).

  5. 5

    Cohen, S. S., and McNair Scott, D. B., Science, 111, 543 (1950).

  6. 6

    Cohen, S. S., and McNair Scott, D. B., Abstr. Comm. 1st Internat. Congress Biochem., Cambridge, 575 (1949).

  7. 7

    Cohen, S. S., and McNair Scott, D. B., Nature, 166, 781 (1950).

  8. 8

    De Ley, J., Nature, 164, 618 (1949).

  9. 9

    De Ley, J., Enzymologia (in the press).

  10. 10

    Racker, E., Fed. Proc., 7, 180 (1948).

  11. 11

    Hough, L., and Jones, J. K. N., Nature, 167, 180 (1951).

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  1. Biochemical Laboratory, Veterinary College, State University, Ghent.

    • J. DE LEY
    •  & S. CORNUT


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