Letter | Published:

Localization of Bacterial Nucleic Acids and Mechanism of the Gram Reaction

Naturevolume 168page464 (1951) | Download Citation



As a consequence of the brilliant studies of Stacey and co-workers, reviewed by Webb1, many investigators of the Gram reaction in bacteria are agreed that the Gram complex is a combination of basic dye and pentose nucleoprotein, apparently localized at or in the cell wall. However, as Lison2 has pointed out, the problem of localization in cytochemistry is a difficult one, and it is not altogether certain that the basophilic component of the Gram complex normally occurs at the cell wall.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Webb, Research, 3, 113 (1950).

  2. 2

    Lison, “Histochimie animale” (Paris, 1936).

  3. 3

    Malmgren and Hedén, Nature, 159, 577 (1947).

  4. 4

    Stearn and Stearn, Protoplasma, 12, 435 (1931).

  5. 5

    Herriott, Adv. Protein Chem., 3, 169 (1947).

  6. 6

    Bradfield, Exp. Cell Res., Supp. 1, 338 (1949).

Download references

Author information


  1. Dental Research Laboratory, Ohio State University, Columbus, 10, Ohio



  1. Search for HEINER HOFFMAN in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.