Letter | Published:

Cocarboxylase in Experimental Diabetes

Naturevolume 168page422 (1951) | Download Citation

Subjects

Abstract

IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act1,2. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Siliprandi, N., Acta Vitaminologica, 4, 259 (1950).

  2. 2

    Siliprandi, D., and Siliprandi, N., Arch. Biol. (in the press).

  3. 3

    Ochoa, S., in “The Biological Action of the Vitamins”, by E. A., Evans, p. 17 (Univ. of Chicago Press, 1944).

  4. 4

    Ochoa, S., and Peters, R. A., Biochem. J., 32, 1501 (1938).

  5. 5

    Siliprandi, D., and Siliprandi, N., Acta Vitaminologica, 5, 3 (1951).

  6. 6

    Margaria, R., Biochem. Z., 270, 444 (1934).

Download references

Author information

Affiliations

  1. Institute of Biological Chemistry, University of Pavia

    • D. SILIPRANDI
    •  & N. SILIPRANDI

Authors

  1. Search for D. SILIPRANDI in:

  2. Search for N. SILIPRANDI in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/168422a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.