Letter | Published:

Cocarboxylase in Experimental Diabetes

Naturevolume 168page422 (1951) | Download Citation



IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act1,2. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis.

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  1. 1

    Siliprandi, N., Acta Vitaminologica, 4, 259 (1950).

  2. 2

    Siliprandi, D., and Siliprandi, N., Arch. Biol. (in the press).

  3. 3

    Ochoa, S., in “The Biological Action of the Vitamins”, by E. A., Evans, p. 17 (Univ. of Chicago Press, 1944).

  4. 4

    Ochoa, S., and Peters, R. A., Biochem. J., 32, 1501 (1938).

  5. 5

    Siliprandi, D., and Siliprandi, N., Acta Vitaminologica, 5, 3 (1951).

  6. 6

    Margaria, R., Biochem. Z., 270, 444 (1934).

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  1. Institute of Biological Chemistry, University of Pavia

    •  & N. SILIPRANDI


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