Abstract
‘MELARSEN’ (disodium - p - melaminylphenylarsonate1, I) is active against tryparsamide-resistant trypanosome strains both in the field2 and in the laboratory3, and is more effective than tryparsamide (sodium p-glycineamidophenylarsonate) in rendering trypanocidal the cerebrospinal fluid in rabbits4. In view of these properties, the behaviour of a ‘Melarsen’-resistant trypanosome strain seemed to merit investigation.
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References
Friedheim, E. A. H., Ann. Inst. Pasteur., 65, 108 (1940).
van Hoof, L., Trans. Roy. Soc. Trop. Med. Hyg., 40, 727 (1947).
Williamson, J., and Lourie, E. M., Nature, 101, 103 (1948).
Rollo, I. M., Williamson, J., and Lourie, E. M., Ann. Trop Med. Parasit., 43, 194 (1949).
Eagle, H., Science, 101, 69 (1945).
Williamson, J., and Lourie, E. M., Ann. Trop. Med. Parasit., 40, 255 (1946).
Lourie, E. M., and Yorke, W., Ann. Trop. Med. Parasit., 32, 201 (1938).
Albert, A., Rubbo, S. D., and Burvill, M. I., Brit. J. Exp. Path., 30, 159 (1949).
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ROLLO, I., WILLIAMSON, J. Acquired Resistance to ‘Melarsen’, Tryparsamide and Amidines in Pathogenic Trypanosomes after Treatment with ‘Melarsen’ Alone. Nature 167, 147–148 (1951). https://doi.org/10.1038/167147a0
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DOI: https://doi.org/10.1038/167147a0
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