Abstract
THE ease with which 1-substituted pyrazoles may be converted into the free imino compounds varies with the nature of the 1-substituent and the reacting substance. Thus, 1,3,5-trimethyl pyrazole may be nitrated1 and 1-phenyl pyrazole reduced to the pyrazoline2 without loss of the N-methyl or N-phenyl groups respectively. On the other hand, pyrazoles of the 1-carbamyl or 1-phenylcarbamyl type, (I), derived from the acyl hydrazides, semicarbazide3 and 4-phenylsemicarbazide4, are much less stable and readily give the free imino derivatives.
Similar content being viewed by others
Article PDF
References
Knorr, Ann., 279, 234 (1894).
Balbiano, Gazz. chim. ital., 18, 358 (1888).
Posner, Ber., 34, 3979 (1901). von Auwers, Ber., 58, 2075 (1925). Dornlow and Peterlein, Ber., 82, 257 (1949).
Wheeler and Norton, J. Amer. Chem. Soc., 50, 2488 (1928).
Thiele and Bihan, Ann., 302, 299 (1898). Thiele and Strange, Ann., 283, 27 (1894). De, Quart J. Ind. Chem. Soc., 4, 183 (1927).
Hantzsch and Vagt, Ann., 314, 339 (1906).
Thiele and Dralle, Ann., 302, 275 (1898). See also De and Rakshit, J. Ind. Chem. Soc., 13, 509 (1936).
O'Connor, Horgan and Reilly, J. App. Chem., 1, 91 (1951).
Scott, F. L., and O'Sullivan, D. A. (unpublished work).
Musante, Gazz. chim. ital., 72, 537 (1942).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCOTT, F., MURPHY, C. & REILLY, J. Carbamidine-substituted Pyrazoles. Nature 167, 1037 (1951). https://doi.org/10.1038/1671037a0
Issue Date:
DOI: https://doi.org/10.1038/1671037a0
This article is cited by
-
A New Route to Substituted Guanidines
Nature (1952)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.