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Beta- and Gamma-Globulin Tetanus Antitoxin of the Hyperimmune Horse


PAST work has indicated that fractionation of diphtheria antitoxic horse serum yields fractions of which the dilution ratio, and hence the firmness of combination, may show considerable variations. There was a definite correlation between the in vitro/in vivo ratio and the dilution ratio1. Kekwick and Record2 examined electrophoretically pure gamma- and beta-globulin from hyperimmune horse sera, and found that both fractions had antitoxic activity and that they differed in their L + /Lf ratios and in their speed of flocculation. It was of interest to investigate whether this was a general phenomenon, or one confined to the diphtheria toxin–antitoxin system, by studying the relation between tetanus toxin and horse tetanus antitoxic sera.


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CINADER, B., WEITZ, B. Beta- and Gamma-Globulin Tetanus Antitoxin of the Hyperimmune Horse. Nature 166, 785 (1950).

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