PAST work has indicated that fractionation of diphtheria antitoxic horse serum yields fractions of which the dilution ratio, and hence the firmness of combination, may show considerable variations. There was a definite correlation between the in vitro/in vivo ratio and the dilution ratio1. Kekwick and Record2 examined electrophoretically pure gamma- and beta-globulin from hyperimmune horse sera, and found that both fractions had antitoxic activity and that they differed in their L + /Lf ratios and in their speed of flocculation. It was of interest to investigate whether this was a general phenomenon, or one confined to the diphtheria toxin–antitoxin system, by studying the relation between tetanus toxin and horse tetanus antitoxic sera.
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CINADER, B., WEITZ, B. Beta- and Gamma-Globulin Tetanus Antitoxin of the Hyperimmune Horse. Nature 166, 785 (1950). https://doi.org/10.1038/166785a0
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