Abstract
PHENOTHIAZINE has a very low solubility, a low toxicity for host animals, and a high dose-rate when used as an anthelmintic. Its anthelmintic action varies among even closely related species of nematodes; in vitro it has little activity. Explanations for these characteristics have been sought by following the uptake and retention of phenothiazine labelled with sulphur-35 by host and parasite tissues. This method has proved suitable for following phenothiazine and its derivatives formed in animal tissues. No evidence has been obtained that sulphur is freed from phenothiazine by the action of biological systems. The ‘phenothiazine’ determined in animal tissues and referred to in this communication includes the unchanged compound and its sulphur-containing derivatives formed in the tissues.
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References
Esserman, H. E., private communication.
Rogers, W. P., and Lazarus, M., Parasit., 39, 345 (1949).
Rogers, W. P., Aust. J. Sci. Res., B, 2, 166 (1949).
Massey, V., and Rogers, W. P., Aust. J. Sci. Res., B (in the press).
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LAZARUS, M., ROGERS, W. Uptake of Phenothiazine Labelled with Sulphur-35 by the Tissues of Nematode Parasites and their Hosts. Nature 166, 647–648 (1950). https://doi.org/10.1038/166647c0
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DOI: https://doi.org/10.1038/166647c0
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